Alterations in the regulation of gene expression are frequently associated with
developmental diseases or cancer. Transcription activation is a key phenomenon in the …

Networks of regulatory enhancers dictate distinct cell identities and cellular responses to
diverse signals by instructing precise spatiotemporal patterns of gene expression. However …

Acetylation of histone H3 at lysine 27 is a well-defined marker of enhancer activity. However,
the functional impact of this modification at enhancers is poorly understood. Here, we use a …

Despite advances in prostate cancer diagnosis and management, morbidity from prostate
cancer remains high. Approximately 20% of men present with advanced or metastatic …

Androgens and androgen receptors (AR) play a pivotal role in expression of the male
phenotype. Several diseases, such as androgen insensitivity syndrome (AIS) and prostate …

The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …

Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in
physiological aspects of cell-type determination and tissue homeostasis, their potential …

Continued reliance on the androgen receptor (AR) is now understood as a core mechanism
in castration-resistant prostate cancer (CRPC), the most advanced form of this disease …

With the explosion of genome-wide studies of regulated transcription, it has become clear
that traditional definitions of enhancers and promoters need to be revisited. These control …

The human body is composed of diverse cell types with distinct functions. Although it is
known that lineage specification depends on cell-specific gene expression, which in turn is …