Cell-mediated immune responses in tuberculosis
AM Cooper - Annual review of immunology, 2009 - annualreviews.org
Tuberculosis is primarily a disease of the lung, and dissemination of the disease depends
on productive infection of this critical organ. Upon aerosol infection with Mycobacterium …
on productive infection of this critical organ. Upon aerosol infection with Mycobacterium …
BCG-induced cross-protection and development of trained immunity: implication for vaccine design
C Covián, A Fernández-Fierro, A Retamal-Díaz… - Frontiers in …, 2019 - frontiersin.org
The Bacillus Calmette-Guérin (BCG) is a live attenuated tuberculosis vaccine that has the
ability to induce non-specific cross-protection against pathogens that might be unrelated to …
ability to induce non-specific cross-protection against pathogens that might be unrelated to …
T cells and adaptive immunity to Mycobacterium tuberculosis in humans
The adaptive immune response mediated by T cells is critical for control of Mycobacterium
tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens …
tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens …
Biomarkers and diagnostics for tuberculosis: progress, needs, and translation into practice
Human infection with Mycobacterium tuberculosis can progress to active disease, be
contained as latent infection, or be eradicated by the host response. Tuberculosis …
contained as latent infection, or be eradicated by the host response. Tuberculosis …
In search of a new paradigm for protective immunity to TB
Clinical trials of vaccines against Mycobacterium tuberculosis are well under way and
results are starting to come in. Some of these results are not so encouraging, as exemplified …
results are starting to come in. Some of these results are not so encouraging, as exemplified …
Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guerin vaccination of newborns
Rationale: Immunogenicity of new tuberculosis (TB) vaccines is commonly assessed by
measuring the frequency and cytokine expression profile of T cells. Objectives: We tested …
measuring the frequency and cytokine expression profile of T cells. Objectives: We tested …
Functional Signatures of Human CD4 and CD8 T Cell Responses to Mycobacterium tuberculosis
T Prezzemolo, G Guggino, MP La Manna… - Frontiers in …, 2014 - frontiersin.org
With 1.4 million deaths and 8.7 million new cases in 2011, tuberculosis (TB) remains a
global health care problem and together with HIV and Malaria represents one of the three …
global health care problem and together with HIV and Malaria represents one of the three …
Efficacy and Safety of BCG Revaccination With M. bovis BCG Moscow to Prevent COVID-19 Infection in Health Care Workers: A Randomized Phase II Clinical Trial
LRB Dos Anjos, AC da Costa, ARO Cardoso… - Frontiers in …, 2022 - frontiersin.org
The Bacillus Calmette-Guérin (BCG) vaccine, which is widely used to protect children
against tuberculosis, can also improve immune response against viral infections. This …
against tuberculosis, can also improve immune response against viral infections. This …
Multifunctional CD4+ T cells correlate with active Mycobacterium tuberculosis infection
Th1 CD4+ T cells and their derived cytokines are crucial for protection against
Mycobacterium tuberculosis. Using multiparametric flow cytometry, we have evaluated the …
Mycobacterium tuberculosis. Using multiparametric flow cytometry, we have evaluated the …
Immune Responses to Bacillus Calmette–Guérin Vaccination: Why Do They Fail to Protect against Mycobacterium tuberculosis?
Mycobacterium tuberculosis (M. tb), the causative agent of tuberculosis (TB), is the current
leading cause of death due to a single infectious organism. Although curable, the broad …
leading cause of death due to a single infectious organism. Although curable, the broad …