Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
TGF-β signaling in control of cardiovascular function
MJ Goumans, P Ten Dijke - Cold Spring Harbor …, 2018 - cshperspectives.cshlp.org
Genetic studies in animals and humans indicate that gene mutations that functionally perturb
transforming growth factor β (TGF-β) signaling are linked to specific hereditary vascular …
transforming growth factor β (TGF-β) signaling are linked to specific hereditary vascular …
Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow
AC Vion, M Kheloufi, A Hammoutene… - Proceedings of the …, 2017 - National Acad Sciences
It has been known for some time that atherosclerotic lesions preferentially develop in areas
exposed to low SS and are characterized by a proinflammatory, apoptotic, and senescent …
exposed to low SS and are characterized by a proinflammatory, apoptotic, and senescent …
P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction
SP Wang, A Iring, B Strilic, JA Juárez… - The Journal of …, 2015 - Am Soc Clin Investig
Elevated blood pressure is a key risk factor for develo** cardiovascular diseases. Blood
pressure is largely determined by vasodilatory mediators, such as nitric oxide (NO), that are …
pressure is largely determined by vasodilatory mediators, such as nitric oxide (NO), that are …
Mechano‐sensing and transduction by endothelial surface glycocalyx: composition, structure, and function
BM Fu, JM Tarbell - Wiley Interdisciplinary Reviews: Systems …, 2013 - Wiley Online Library
The endothelial cells (ECs) lining every blood vessel wall are constantly exposed to the
mechanical forces generated by blood flow. The EC responses to these hemodynamic …
mechanical forces generated by blood flow. The EC responses to these hemodynamic …
Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish
LA Samsa, C Givens, E Tzima, DYR Stainier… - …, 2015 - journals.biologists.com
Congenital heart disease often features structural abnormalities that emerge during
development. Accumulating evidence indicates a crucial role for cardiac contraction and the …
development. Accumulating evidence indicates a crucial role for cardiac contraction and the …
Endothelial Surface Glycocalyx Can Regulate Flow-Induced Nitric Oxide Production in Microvessels In Vivo
W Yen, B Cai, J Yang, L Zhang, M Zeng, JM Tarbell… - PloS one, 2015 - journals.plos.org
Due to its unique location, the endothelial surface glycocalyx (ESG) at the luminal side of the
microvessel wall may serve as a mechano-sensor and transducer of blood flow and thus …
microvessel wall may serve as a mechano-sensor and transducer of blood flow and thus …
The role of endothelial surface glycocalyx in mechanosensing and transduction
The endothelial cells (ECs) forming the inner wall of every blood vessel are constantly
exposed to the mechanical forces generated by blood flow. The EC responses to these …
exposed to the mechanical forces generated by blood flow. The EC responses to these …
Microvascular endothelial cells migrate upstream and align against the shear stress field created by im**ing flow
At present, little is known about how endothelial cells respond to spatial variations in fluid
shear stress such as those that occur locally during embryonic development, at heart valve …
shear stress such as those that occur locally during embryonic development, at heart valve …
Fluid shear stress induces upregulation of COX-2 and PGI2 release in endothelial cells via a pathway involving PECAM-1, PI3K, FAK, and p38
S Russell-Puleri, NG dela Paz… - American Journal …, 2017 - journals.physiology.org
Vascular endothelial cells play an important role in the regulation of vascular function in
response to mechanical stimuli in both healthy and diseased states. Prostaglandin I2 (PGI2) …
response to mechanical stimuli in both healthy and diseased states. Prostaglandin I2 (PGI2) …