Early diagnosis of pancreatic cancer: clinical premonitions, timely precursor detection and increased curative-intent surgery

K Søreide, W Ismail, M Roalsø, J Ghotbi… - Cancer …, 2023 - journals.sagepub.com
Background The overall poor prognosis in pancreatic cancer is related to late clinical
detection. Early diagnosis remains a considerable challenge in pancreatic cancer …

Biomarkers of obesity-mediated insulin resistance: focus on microRNAs

Y Cai, P Liu, Y Xu, Y **a, X Peng, H Zhao… - Diabetology & Metabolic …, 2023 - Springer
Obesity and metabolic syndromes are becoming increasingly prevalent worldwide. Insulin
resistance (IR) is a common complication of obesity. However, IR occurrence varies across …

An Enzyme‐Activatable Aggregation‐Induced‐Emission Probe: Intraoperative Pathological Fluorescent Diagnosis of Pancreatic Cancer via Specific Cathepsin E

Z Zhu, Q Wang, X Chen, Q Wang, C Yan… - Advanced …, 2022 - Wiley Online Library
Pancreatic cancer (PC) is one of the most devastating malignant tumors. However,
fluorescence probes for early clinical diagnosis of PC often encounter difficulties in accuracy …

Blood-based diagnosis and risk stratification of patients with pancreatic intraductal papillary mucinous neoplasm (IPMN)

C Zhang, FN Al-Shaheri, MSS Alhamdani… - Clinical Cancer …, 2023 - AACR
Purpose: Intraductal papillary mucinous neoplasm (IPMN) is a precursor of pancreatic ductal
adenocarcinoma. Low-grade dysplasia has a relatively good prognosis, whereas high …

Comparative performance of endoscopic ultrasound-based techniques in patients with pancreatic cystic lesions: a network meta-analysis

S Li, Z Wang, C Pan, C Wu, Z Li, Z **… - Official journal of the …, 2023 - journals.lww.com
METHODS: A comprehensive literature search was performed for all comparative studies
assessing the accuracy of 2 or more modalities for PCL diagnosis. The primary outcome was …

Nanoparticle-based delivery systems modulate the tumor microenvironment in pancreatic cancer for enhanced therapy

M Jia, D Zhang, C Zhang, C Li - Journal of Nanobiotechnology, 2021 - Springer
Pancreatic cancer is one of the most lethal malignant tumors with a low survival rate, partly
because the tumor microenvironment (TME), which consists of extracellular matrix (ECM) …

Clinical and molecular attributes and evaluation of pancreatic cystic neoplasm

P Raut, RK Nimmakayala, SK Batra… - Biochimica et Biophysica …, 2023 - Elsevier
Intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs)
are all considered “Pancreatic cystic neoplasms (PCNs)” and show a varying risk of …

Development of a Serum-Based MicroRNA Signature for Early Detection of Pancreatic Cancer: A Multicenter Cohort Study

J Huang, G Gao, Y Ge, J Liu, H Cui, R Zheng… - Digestive Diseases and …, 2024 - Springer
Background A grim prognosis of pancreatic cancer (PCa) was attributed to the difficulty in
early diagnosis of the disease. Aims Identifying novel biomarkers for early detection of PCa …

Salivary polyamines help detect high-risk patients with pancreatic cancer: a prospective validation study

D Nose, M Sugimoto, T Muta, SI Miura - International journal of molecular …, 2023 - mdpi.com
Pancreatic cancer is one of the most malignant cancer types and has a poor prognosis. It is
often diagnosed at an advanced stage because of the absence of typical symptoms …

Imaging modalities for early detection of pancreatic cancer: Current state and future research opportunities

KP Farr, D Moses, KS Haghighi, PA Phillips… - Cancers, 2022 - mdpi.com
Simple Summary While survival rates for many cancers have improved dramatically over the
last 20 years, patients with pancreatic cancer have persistently poor outcomes. The majority …