There are several well-documented functions of high-density lipoprotein (HDL) that may
explain the ability of these lipoproteins to protect against atherosclerosis. The best …

The metabolism of high-density lipoproteins (HDL), which are inversely related to risk of
atherosclerotic cardiovascular disease, involves a complex interplay of factors regulating …

Organophosphorus compounds are extensively used worldwide as pesticides which cause
great hazards to human health. Nerve agents, a subcategory of the organophosphorus …

Sporadic amyotrophic lateral sclerosis (ALS) is one of the most devastating neurological
diseases; most patients die within 3 to 4 years after symptom onset. Oxidative stress is a …

Members of the serum paraoxonase (PON) family have been identified in mammals and
other vertebrates, and in invertebrates. PONs exhibit a wide range of physiologically …

The retinal pigment epithelium-photoreceptor interphase is renewed each day in a stunning
display of cellular interdependence. While photoreceptors use photosensitive pigments to …

The paraoxonase (PON) gene family in humans has three members, PON1, PON2, and
PON3. Their physiological role (s) and natural substrates are uncertain. We developed a …

Abstract Paraoxonase-1 (PON1), an esterase/lactonase primarily associated with plasma
high-density lipoprotein (HDL), was the first member of this family of enzymes to be …

Context Paraoxonase 1 (PON1) is reported to have antioxidant and cardioprotective
properties. The relationship between PON1 genotypes and functional activity with systemic …

The human paraoxonase (PON) gene family consists of three members, PON1, PON2, and
PON3, aligned next to each other on chromosome 7. By far the most-studied member of the …