Risk factor analysis provides an important basis for develo** interventions for any
condition. In the case of myopia, evidence for a large number of risk factors has been …

Background Mutations in the L/M cone opsin gene array cause abnormally high perceived
retinal contrast and the development of myopia. Environmental factors may also lead to high …

Light absorption by photopigment molecules expressed in the photoreceptors in the retina is
the first step in seeing. Two types of photoreceptors in the human retina are responsible for …

Myopia is a globally emerging concern accompanied by multiple medical and socio-
economic burdens with no well-established causal treatment to control thus far. The study of …

Pathogenic variants in the OPN1LW/OPN1MW gene cluster are causal for a range of mild to
severe visual impairments with color deficiencies. The widely utilized short-read next …

Mutations which induce aberrant transcript splicing represent a distinct class of disease-
causing genetic variants in retinal disease genes. Such mutations may either weaken or …

In syndromic forms of myopia caused by long (L) to middle (M) wavelength (L/M)
interchange mutations, erroneous contrast signals from ON-bipolar cells activated by cones …

The balance of ON/OFF pathway activation in the retina plays a role in emmetropization. A
new myopia control lens design uses contrast reduction to down-regulate a hypothesized …

Blue cone monochromacy (BCM) is a congenital vision disorder characterized by complete
loss or severely reduced long-and middle-wavelength cone function, caused by mutations in …

Inherited cone disorders (ICDs) are a heterogeneous sub-group of inherited retinal
disorders (IRDs), the leading cause of sight loss in children and working-age adults. ICDs …