The actin cytoskeleton is a complex structure that performs a wide range of cellular
functions. In 2001, significant advances were made to our understanding of the structure and …

Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

Synapses store information by long-lasting modifications of their structure and molecular
composition, but the precise chronology of these changes has not been studied at single …

We used cryo-electron microscopy (cryo-EM) to reconstruct actin filaments with bound
AMPPNP (β, γ-imidoadenosine 5′-triphosphate, an ATP analog, resolution 3.1 Å), ADP-Pi …

The actin depolymerizing factor (ADF)/cofilin family comprises small actin-binding proteins
with crucial roles in development, tissue homeostasis and disease. They are best known for …

ADF/cofilins are key regulators of actin dynamics during cellular motility, yet their precise
role and mechanism of action are shrouded in ambiguity. Direct observation of actin …

The last decades have witnessed an exponential increase in our knowledge of Rho GTPase
signaling network which further highlighted the cross talk between these proteins and the …

Intracellular and extracellular mechanical forces affect the structure and dynamics of the
actin cytoskeleton. However, the underlying molecular and biophysical mechanisms …

Generating force and movement is essential for the functions of cells and organisms. A
variety of molecular motors that can move on tracks within cells have evolved to serve this …

The ADF/cofilins are a family of actin-binding proteins expressed in all eukaryotic cells so far
examined. Members of this family remodel the actin cytoskeleton, for example during …