Cannabinoid ligands targeting TRP channels
Transient receptor potential (TRP) channels are a group of membrane proteins involved in
the transduction of a plethora of chemical and physical stimuli. These channels modulate ion …
the transduction of a plethora of chemical and physical stimuli. These channels modulate ion …
Cannabinoids, the endocannabinoid system, and pain: a review of preclinical studies
This narrative review represents an output from the International Association for the Study of
Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based …
Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based …
Cannabis‐based medicines for chronic neuropathic pain in adults
M Mücke, T Phillips, L Radbruch… - … of systematic reviews, 2018 - cochranelibrary.com
Background This review is one of a series on drugs used to treat chronic neuropathic pain.
Estimates of the population prevalence of chronic pain with neuropathic components range …
Estimates of the population prevalence of chronic pain with neuropathic components range …
Phytochemistry of Cannabis sativa L.
Cannabis (Cannabis sativa, or hemp) and its constituents—in particular the cannabinoids—
have been the focus of extensive chemical and biological research for almost half a century …
have been the focus of extensive chemical and biological research for almost half a century …
Structure of a signaling cannabinoid receptor 1-G protein complex
Cannabis elicits its mood-enhancing and analgesic effects through the cannabinoid receptor
1 (CB1), a G protein-coupled receptor (GPCR) that signals primarily through the adenylyl …
1 (CB1), a G protein-coupled receptor (GPCR) that signals primarily through the adenylyl …
[HTML][HTML] Cannabinoid delivery systems for pain and inflammation treatment
There is a growing body of evidence to suggest that cannabinoids are beneficial for a range
of clinical conditions, including pain, inflammation, epilepsy, sleep disorders, the symptoms …
of clinical conditions, including pain, inflammation, epilepsy, sleep disorders, the symptoms …
Medicinal properties of cannabinoids, terpenes, and flavonoids in cannabis, and benefits in migraine, headache, and pain: an update on current evidence and …
EP Baron - Headache: The Journal of Head and Face Pain, 2018 - Wiley Online Library
Background Comprehensive literature reviews of historical perspectives and evidence
supporting cannabis/cannabinoids in the treatment of pain, including migraine and …
supporting cannabis/cannabinoids in the treatment of pain, including migraine and …
Structural basis for activation of CB1 by an endocannabinoid analog
Endocannabinoids (eCBs) are endogenous ligands of the cannabinoid receptor 1 (CB1), a
G protein-coupled receptor that regulates a number of therapeutically relevant physiological …
G protein-coupled receptor that regulates a number of therapeutically relevant physiological …
From phytocannabinoids to cannabinoid receptors and endocannabinoids: pleiotropic physiological and pathological roles through complex pharmacology
Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …
The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain
A great need exists for the development of new medications to treat pain resulting from
various disease states and types of injury. Given that the endogenous cannabinoid (that is …
various disease states and types of injury. Given that the endogenous cannabinoid (that is …