Acetylcholine acts as a neurotransmitter in the central and peripheral nervous systems in
humans. However, recent experiments demonstrate a widespread expression of the …

In the 1980s, studies in the vascular field revealed that the endothelium was not simply a
metabolic and physical barrier, but liberated substances that could modulate the function of …

Asthma is a chronic obstructive airway disease characterised by airway
hyperresponsiveness (AHR) and airway wall remodelling. The effector of airway narrowing …

Various bronchoactive agents can induce the release from the airway epithelium of an
inhibitory substance that is able to relax certain tissues including rat aorta and possibly also …

The responsiveness of airway smooth muscle is influenced by the functional integrity of the
respiratory epithelium. The nature of this regulatory action by the epithelium remains largely …

The purpose of the present experiments was to study the underlying mechanisms
responsible for the relaxant action of endothelin-1 (ET-1) in the guinea-pig trachea in vitro. 2 …

1 Airway narrowing was determined in vitro as a measure of bronchial reactivity. A bronchial
segment from pig lung was perfused with a Krebs solution and the change in flow rate to …

Since the first issue on histamine in the Handbook of Pharmacology (R ocha ES ilva 1966),
in which only eight pages were devoted to brain histamine (White 1966), great progress has …

The influence of epithelium on the effects of H3-histamine receptor agonist (R) alpha-
methylhistamine [(R) alpha-MeHist] on airways was investigated on the guinea-pig perfused …

1. The effects of epithelial cells were investigated on resting membrane potential and neuro‐
effector transmission in smooth muscle cells of the dog tracheal and bronchiolar tissues. 2 …