Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful
model system to uncover fundamental mechanisms that control cellular identity during …

Abstract Tet enzymes (Tet1/2/3) oxidize 5-methylcytosine to promote DNA demethylation
and partner with chromatin modifiers to regulate gene expression. Tet1 is highly expressed …

Kaposi sarcoma-associated herpesvirus (KSHV) establishes a latent infection in the cell
nucleus, but where KSHV episomal genomes are tethered and the mechanisms underlying …

The nucleosome remodeling and deacetylase (NuRD) complex is one of the central
chromatin remodeling complexes that mediates gene repression. NuRD is essential for …

During transcription, DNA replication and repair, chromatin structure is constantly modified
to reveal specific genetic regions and allow access to DNA-interacting enzymes. ATP …

Aims Chemoresistance remains a major challenge in gastric cancer (GC). Chromodomain
helicase DNA-binding protein 4 (CHD4) mediated chromatin remodeling plays critical roles …

Mutations in enzymes that modify histone H3 at lysine 4 (H3K4) or lysine 36 (H3K36) have
been linked to human disease, yet the role of these residues in mammals is unclear. We …

Cell lineage specification is a tightly regulated process that is dependent on appropriate
expression of lineage and developmental stage-specific transcriptional programs. Here, we …

Cellular totipotency is critical for whole-organism generation, yet how totipotency is
established remains poorly illustrated. Abundant transposable elements (TEs) are activated …

Recruitment of RNA polymerase II to hypoxia-inducible factor (HIF) target genes under
normoxia is a prerequisite for HIF-mediated transactivation. However, the underlying …