Toxicity testing in the 21st century: progress in the past decade and future perspectives

D Krewski, ME Andersen, MG Tyshenko… - Archives of …, 2020 - Springer
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA

JR Sobus, JF Wambaugh, KK Isaacs… - Journal of exposure …, 2018 - nature.com
Tens-of-thousands of chemicals are registered in the US for use in countless processes and
products. Recent evidence suggests that many of these chemicals are measureable in …

The CompTox Chemistry Dashboard: a community data resource for environmental chemistry

AJ Williams, CM Grulke, J Edwards… - Journal of …, 2017 - Springer
Despite an abundance of online databases providing access to chemical data, there is
increasing demand for high-quality, structure-curated, open data to meet the various needs …

The next generation blueprint of computational toxicology at the US Environmental Protection Agency

RS Thomas, T Bahadori, TJ Buckley… - Toxicological …, 2019 - academic.oup.com
Abstract The US Environmental Protection Agency (EPA) is faced with the challenge of
efficiently and credibly evaluating chemical safety often with limited or no available toxicity …

The Chemical and Products Database, a resource for exposure-relevant data on chemicals in consumer products

KL Dionisio, K Phillips, PS Price, CM Grulke, A Williams… - Scientific data, 2018 - nature.com
Quantitative data on product chemical composition is a necessary parameter for
characterizing near-field exposure. This data set comprises reported and predicted …

[HTML][HTML] Chemicals of concern in plastic toys

N Aurisano, L Huang, LM i Canals, O Jolliet… - Environment …, 2021 - Elsevier
We present a list of Chemicals of Concern (CoCs) in plastic toys. We started from available
studies reporting chemical composition of toys to group plastic materials, as well as to gather …

Allergic diseases: a comprehensive review on risk factors, immunological mechanisms, link with COVID-19, potential treatments, and role of allergen bioinformatics

FM Aldakheel - International journal of environmental research and …, 2021 - mdpi.com
The prevalence of allergic diseases is regarded as one of the key challenges in health
worldwide. Although the precise mechanisms underlying this rapid increase in prevalence …

Suspect screening analysis of chemicals in consumer products

KA Phillips, A Yau, KA Favela, KK Isaacs… - … science & technology, 2018 - ACS Publications
A two-dimensional gas chromatography-time-of-flight/mass spectrometry (GC× GC-TOF/MS)
suspect screening analysis method was used to rapidly characterize chemicals in 100 …

[HTML][HTML] Health risks of chemicals in consumer products: A review

D Li, S Suh - Environment international, 2019 - Elsevier
Increasingly diverse chemicals are used in consumer products, while our understanding of
their exposure pathways and associated human health risks still lags behind. This paper …

[HTML][HTML] Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

E Fritsche, P Grandjean, KM Crofton, M Aschner… - Toxicology and applied …, 2018 - Elsevier
This consensus statement voices the agreement of scientific stakeholders from regulatory
agencies, academia and industry that a new framework needs adopting for assessment of …