Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in
lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its …

This article reviews the discovery of PCSK9, its structure–function characteristics, and its
presently known and proposed novel biological functions. The major critical function of …

Proteolytic removal of membrane protein ectodomains (ectodomain shedding) is a post‐
translational modification that controls levels and function of hundreds of membrane …

Apolipoprotein E (apoE) is a major apolipoprotein involved in lipoprotein metabolism. It is a
polymorphic protein and different isoforms are associated with variations in lipid and …

Evidence suggests that caffeine (CF) reduces cardiovascular disease (CVD) risk. However,
the mechanism by which this occurs has not yet been uncovered. Here, we investigated the …

Abstract Purpose of Review Since the discovery of PCSK9 in 2003, this proprotein
convertase was shown to target specific receptors for degradation in endosomes/lysosomes …

Hyperlipidemia, the most common form of dyslipidemia, is the main source of cardiovascular
disorders, characterized by elevated level of total cholesterol (TC), triglycerides (TG) and low …

910 levels, whereas PCSK9 overexpression did not cause an increase in plasma lipids but
in atherosclerotic lesion size18, 19). The Atheroma IVUS study revealed that the necrotic …

The relevance of PCSK9 in atherosclerosis progression is demonstrated by the benefits
observed in patients that have followed PCSK9-targeted therapies. The impact of these …

Background: Both PCSK9 and NLRP3 inflammasome play important roles in atherogenesis.
This study was designed to test the hypothesis that NLRP3 inflammasome via IL-1β induces …