African trypanosomes are bloodstream protozoan parasites that infect mammals including
humans, where they cause slee** sickness. Long-lasting infection is required to favor …

African trypanosomes are vector-borne protozoa, which cause significant human and animal
disease across sub-Saharan Africa, and animal disease across Asia and South America. In …

Human African trypanosomiasis, or slee** sickness, is caused by the protozoan parasite
Trypanosoma brucei and induces profound reactivity of glial cells and neuroinflammation …

The kinetoplastid parasite, Trypanosoma brucei, undergoes a complex life cycle entailing
slender and stumpy bloodstream forms in mammals and procyclic and metacyclic forms …

Abstract Treatment failure (TF) jeopardizes the management of parasitic diseases, including
leishmaniasis. From the parasite's point of view, drug resistance (DR) is generally …

In infectious diseases, extracellular vesicles (EVs) released from a pathogen or pathogen-
infected cells can transfer pathogen-derived biomolecules, especially proteins, to target cells …

Parasitic diseases caused by kinetoplastid parasites are a burden to public health
throughout tropical and subtropical regions of the world. TriTrypDB (https://tritrypdb. org) is a …

African trypanosomes proliferate as bloodstream forms (BSFs) and procyclic forms in the
mammal and tsetse fly midgut, respectively. This allows them to colonise the host …

Although genome-wide polycistronic transcription places major emphasis on post-
transcriptional controls in trypanosomatids, messenger RNA cis-regulatory untranslated …

The development of Trypanosoma brucei in its mammalian host is marked by a distinct
morphological change as replicative “slender” forms differentiate into cell cycle arrested …