Abstract Ciprofloxacin (CIP)(human use) and enrofloxacin (ENR)(veterinary use) are
synthetic anti-infectious medications that belong to the second generation of …

Highlights•Antibiotic persistence is well described in vitro, but challenging to study in
vivo.•Salmonella Typhimurium is an ideal organism for studying antibiotic …

In vivo, antibiotics are often much less efficient than ex vivo and relapses can occur. The
reasons for poor in vivo activity are still not completely understood. We have studied the …

Antibiotics are powerful therapeutics but are not equally effective against all cells in bacterial
populations. Bacteria that express an antibiotic-tolerant phenotype (" persisters") can evade …

Topological, chemical and immunological barriers are thought to limit infection by
enteropathogenic bacteria. However, in many cases these barriers and their consequences …

Antibiotic therapy is usually not recommended for salmonellosis, as it is associated with
prolonged fecal carriage without reducing symptom duration or severity. Here we show that …

Targeted antibiotic delivery system would be an ideal solution for the treatment of
enteropathogenic infections since it avoids the excessive usage of antibiotics clinically …

'Omics' tools are being developed at an ever increasing pace. Collectively, genome
sequencing, genome-wide transcriptional analysis (transcriptomics), proteomics …

Many plasmids encode antibiotic resistance genes. Through conjugation, plasmids can be
rapidly disseminated. Previous work identified gut luminal donor/recipient blooms and tissue …

Salmonella enterica serovar Typhimurium has been extensively exploited as live attenuated
vaccines (LAV) which generally confers better protection than killed or subunit vaccines …