Diabetic retinopathy: vascular and inflammatory disease
Diabetic retinopathy (DR) is the leading cause of visual impairment in the working‐age
population of the Western world. The pathogenesis of DR is complex and several vascular …
population of the Western world. The pathogenesis of DR is complex and several vascular …
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
D Hanahan, J Folkman - cell, 1996 - cell.com
Introduction confirmed this result and further revealed that in the Blood vessels are
fundamentally composed of endotheabsence of access to an adequate vasculature, tumor …
fundamentally composed of endotheabsence of access to an adequate vasculature, tumor …
Mechanisms of angiogenesis
W Risau - Nature, 1997 - nature.com
After the develo** embryo has formed a primary vascular plexus by a process termed
vasculogenesis, further blood vessels are generated by both sprouting and non-sprouting …
vasculogenesis, further blood vessels are generated by both sprouting and non-sprouting …
Tumorigenesis and the angiogenic switch
G Bergers, LE Benjamin - Nature reviews cancer, 2003 - nature.com
It has become evident that we cannot understand tumour growth without considering
components of the stromal microenvironment, such as the vasculature. At the same time, the …
components of the stromal microenvironment, such as the vasculature. At the same time, the …
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
JA Forsythe, BH Jiang, NV Iyer, F Agani… - … and cellular biology, 1996 - Taylor & Francis
Expression of vascular endothelial growth factor (VEGF) is induced in cells exposed to
hypoxia or ischemia. Neovascularization stimulated by VEGF occurs in several important …
hypoxia or ischemia. Neovascularization stimulated by VEGF occurs in several important …
The biology of vascular endothelial growth factor
N Ferrara, T Davis-Smyth - Endocrine reviews, 1997 - academic.oup.com
Biology of Vascular Endothelial Growth Factor | Endocrine Reviews | Oxford Academic Skip to
Main Content Advertisement Oxford Academic Journals Books Search Menu Information …
Main Content Advertisement Oxford Academic Journals Books Search Menu Information …
Vascular endothelial growth factor (VEGF) and its receptors
Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular
endothelial cells. Five VEGF isoforms are generated as a result of alternative splicing from a …
endothelial cells. Five VEGF isoforms are generated as a result of alternative splicing from a …
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
NV Iyer, LE Kotch, F Agani, SW Leung… - Genes & …, 1998 - genesdev.cshlp.org
Hypoxia is an essential developmental and physiological stimulus that plays a key role in
the pathophysiology of cancer, heart attack, stroke, and other major causes of mortality …
the pathophysiology of cancer, heart attack, stroke, and other major causes of mortality …
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
GL Semenza, BH Jiang, SW Leung… - Journal of Biological …, 1996 - ASBMB
Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor which is
expressed when mammalian cells are subjected to hypoxia and which activates …
expressed when mammalian cells are subjected to hypoxia and which activates …
The role of vascular endothelial growth factor in wound healing
BACKGROUND: A chronic wound is tissue with an impaired ability to heal. This is often a
consequence of one of the following etiologies: diabetes, venous reflux, arterial insufficiency …
consequence of one of the following etiologies: diabetes, venous reflux, arterial insufficiency …