Global Cancer Statistics 2022: the trends projection analysis

BS Chhikara, K Parang - Chemical Biology Letters, 2023 - pubs.thesciencein.org
Cancer is one of the most fatal diseases of recent times that causes several deaths every
year. The disease variations in different parts of the world, the impact of available medical …

Targeting signaling pathways in prostate cancer: mechanisms and clinical trials

Y He, W Xu, YT **ao, H Huang, D Gu… - Signal transduction and …, 2022 - nature.com
Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

[HTML][HTML] PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective

X Han, W Wei, Y Sun - Acta materia medica, 2022 - ncbi.nlm.nih.gov
Abstract Mouse double minute 2 (MDM2) is an E3 ubiquitin ligase which effectively
degrades tumor suppressor p53. In the past two decades, many MDM2 inhibitors that disrupt …

Recent advances and future perspectives in the therapeutics of prostate cancer

GL Varaprasad, VK Gupta, K Prasad, E Kim… - … Hematology & Oncology, 2023 - Springer
Prostate cancer (PC) is one of the most common cancers in males and the fifth leading
reason of death. Age, ethnicity, family history, and genetic defects are major factors that …

Prostate cancer and the cell cycle: focusing on the role of microRNAs

IM Elazab, OA El-Feky, EG Khedr, NE El-Ashmawy - Gene, 2024 - Elsevier
Prostate cancer is the most frequent solid tumor in terms of incidence and ranks second only
to lung cancer in terms of cancer mortality among men. It has a considerably high mortality …

Nuclei segmentation using attention aware and adversarial networks

E Goceri - Neurocomputing, 2024 - Elsevier
Accurate segmentation of nuclei plays a critical role in pathology since assessments and
diagnoses are mainly based on the recognition, measurement, and counting of nuclei …

Advances in mRNA-based cancer vaccines

L Ni - Vaccines, 2023 - mdpi.com
Cancer is a leading cause of death worldwide, accounting for millions of deaths every year.
Immunotherapy is a groundbreaking approach for treating cancer through harnessing the …

Targeting glioblastoma multiforme using a novel fusion protein comprising interleukin-13 and staphylococcal enterotoxin B in vitro

Z Gholipour, AAI Fooladi, K Parivar, R Halabian - Toxicology in Vitro, 2023 - Elsevier
Targeting cell surface receptors with immunotoxins provides a novel, unique and highly
potent treatment against cancers. A high expression of interleukin-13 (IL13) receptor α2 …

Multi-omics strategy reveals that Cordyceps sinensis ameliorates sepsis-associated acute kidney injury via reprogramming of mitochondrial energy metabolism and …

L Chen, T Yang, J Wu, G Cheng, M Zhao… - Acta Materia …, 2024 - scienceopen.com
Cordyceps sinensis (CS) has been widely used as a dietary supplement or traditional
medicine for the prevention, treatment, and prognostication of various diseases, because of …

Glycyl-tRNA Synthetase (GARS) Expression Is Associated with Prostate Cancer Progression and Its Inhibition Decreases Migration, and Invasion In Vitro

E Khosh Kish, Y Gamallat, M Choudhry… - International Journal of …, 2023 - mdpi.com
Glycyl-tRNA synthetase (GARS) is a potential oncogene associated with poor overall
survival in various cancers. However, its role in prostate cancer (PCa) has not been …