Cancer stem cell (CSC) resistance drivers
M Najafi, K Mortezaee, J Majidpoor - Life sciences, 2019 - Elsevier
Cancer stem cells (CSCs) are a population of self-renewal cells with high tumorigenic
potency. CSCs can adopt easily with changes in the nearby milieu, and are more resistant to …
potency. CSCs can adopt easily with changes in the nearby milieu, and are more resistant to …
Versatile function of NF-ĸB in inflammation and cancer
Nuclear factor-kappaB (NF-ĸB) plays a crucial role in both innate and adaptive immune
systems, significantly influencing various physiological processes such as cell proliferation …
systems, significantly influencing various physiological processes such as cell proliferation …
A role for NF-κB in organ specific cancer and cancer stem cells
C Kaltschmidt, C Banz-Jansen, T Benhidjeb, M Beshay… - Cancers, 2019 - mdpi.com
Cancer stem cells (CSCs) account for tumor initiation, invasiveness, metastasis, and
recurrence in a broad range of human cancers. Although being a key player in cancer …
recurrence in a broad range of human cancers. Although being a key player in cancer …
EZH2 and NF-κB: A context-dependent crosstalk and transcriptional regulation in cancer
Epigenetic modifications regulate critical biological processes that play a pivotal role in the
pathogenesis of cancer. Enhancer of Zeste Homolog 2 (EZH2), a subunit of the Polycomb …
pathogenesis of cancer. Enhancer of Zeste Homolog 2 (EZH2), a subunit of the Polycomb …
[HTML][HTML] HIF1α/HIF2α induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions
P Wang, S Gong, B Liao, J Pan, J Wang, D Zou… - Journal of …, 2022 - ncbi.nlm.nih.gov
Objective: Our previous study showed that glioma stem-like cells could be induced to
undergo dedifferentiation under hypoxic conditions, but the mechanism requires further …
undergo dedifferentiation under hypoxic conditions, but the mechanism requires further …
Astrocytes and the tumor microenvironment inflammatory state dictate the killing of glioblastoma cells by Smac mimetic compounds
Smac mimetic compounds (SMCs) are small molecule drugs that sensitize cancer cells to
TNF-α-induced cell death and have multiple immunostimulatory effects through alterations in …
TNF-α-induced cell death and have multiple immunostimulatory effects through alterations in …
Microfluidic-derived docosahexaenoic acid liposomes for targeting glioblastoma and Its inflammatory microenvironment
Glioblastoma (GBM) is the most common malignant primary brain tumor, characterized by
limited treatment options and a poor prognosis. Its aggressiveness is attributed not only to …
limited treatment options and a poor prognosis. Its aggressiveness is attributed not only to …
Residual disease in glioma recurrence: A dangerous liaison with senescence
DA Putavet, PLJ de Keizer - Cancers, 2021 - mdpi.com
Simple Summary Glioblastoma (GBM) is an aggressive and mostly incurable from of brain
cancer. This is largely due to individual tumor cells invading the surrounding tissue, through …
cancer. This is largely due to individual tumor cells invading the surrounding tissue, through …
Extracellular vesicles induce mesenchymal transition and therapeutic resistance in glioblastomas through NF‐κB/STAT3 signaling
Glioblastoma (GBM) is the most common primary malignant brain tumor and despite optimal
treatment, long‐term survival remains uncommon. GBM can be roughly divided into three …
treatment, long‐term survival remains uncommon. GBM can be roughly divided into three …
The STAT3 inhibitor Stattic acts independently of STAT3 to decrease histone acetylation and modulate gene expression
Signal transducer and activator of transcription 3 (STAT3) is an important transcription factor
involved in many physiological functions including embryonic development and immune …
involved in many physiological functions including embryonic development and immune …