The conserved oligomeric Golgi (COG) complex, a multisubunit tethering complex of the
CATCHR (complexes associated with tethering containing helical rods) family, controls …

Cells don't simply separate at cytokinesis. While furrow contraction critically relies on myosin-
II and F-actin, post-furrowing steps are less understood but involve the constriction of …

GOLPH3 is a peripheral membrane protein localized to the Golgi and its vesicles, but its
purpose had been unclear. We found that GOLPH3 binds specifically to the …

Glycosylation is the most common post-translational modification of proteins; it mediates
their correct folding and stability, as well as their transport through the secretory transport …

The plasma membrane of eukaryotic cells is composed of a large number of lipid species
that are laterally segregated into functional domains as well as asymmetrically distributed …

BACKGROUND RAB GTPases constitute the largest family of small GTPases and are found
in all eukaryotes. RAB GTPases regulate components of the endomembrane system, the …

The evolutionarily conserved target of rapamycin (TOR) serine/threonine kinase controls
eukaryotic cell growth, metabolism and survival by integrating signals from the nutritional …

The oncoprotein GOLPH3 (Golgi phosphoprotein 3) is an evolutionarily conserved
phosphatidylinositol 4-phosphate effector, mainly localized to the Golgi apparatus, where it …

Drosophila dividing spermatocytes offer a highly suitable cell system in which to investigate
the coordinated reorganization of microtubule and actin cytoskeleton systems during cell …

The duplication cycle is the fascinating process that, starting from a cell, results in the
formation of two daughter cells and it is essential for life. Cytokinesis is the final step of the …