Turnitin
降AI改写
早检测系统
早降重系统
Turnitin-UK版
万方检测-期刊版
维普编辑部版
Grammarly检测
Paperpass检测
checkpass检测
PaperYY检测
Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration
H Querfurth, HK Lee - Molecular neurodegeneration, 2021 - Springer
Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …
misfolded protein accumulations may be found in the diverse signaling pathways of the …
Targeting autophagy in disease: established and new strategies
Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
cytosolic aggregated proteins, damaged organelles or invading microorganisms …
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
B Boland, WH Yu, O Corti, B Mollereau… - Nature reviews Drug …, 2018 - nature.com
Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …
Pathways of cellular proteostasis in aging and disease
CL Klaips, GG Jayaraj, FU Hartl - Journal of Cell Biology, 2018 - rupress.org
Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …
[HTML][HTML] Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis
S Masaldan, SAS Clatworthy, C Gamell, PM Meggyesy… - Redox biology, 2018 - Elsevier
Cellular senescence is characterised by the irreversible arrest of proliferation, a pro-
inflammatory secretory phenotype and evasion of programmed cell death mechanisms. We …
inflammatory secretory phenotype and evasion of programmed cell death mechanisms. We …
Autophagy in neurodegenerative diseases: pathogenesis and therapy
F Guo, X Liu, H Cai, W Le - Brain pathology, 2018 - Wiley Online Library
The most prevalent pathological features of many neurodegenerative diseases are the
aggregation of misfolded proteins and the loss of certain neuronal populations. Autophagy …
aggregation of misfolded proteins and the loss of certain neuronal populations. Autophagy …
[HTML][HTML] A comprehensive review of autophagy and its various roles in infectious, non-infectious, and lifestyle diseases: current knowledge and prospects for disease …
Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …
Autophagy induction as a therapeutic strategy for neurodegenerative diseases
A Djajadikerta, S Keshri, M Pavel, R Prestil… - Journal of molecular …, 2020 - Elsevier
Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …
contents to lysosomes for degradation. Genetic studies have revealed extensive links …
Targeted degradation of⍺-synuclein aggregates in Parkinson's disease using the AUTOTAC technology
J Lee, KW Sung, EJ Bae, D Yoon, D Kim… - Molecular …, 2023 - Springer
Background There are currently no disease-modifying therapeutics for Parkinson's disease
(PD). Although extensive efforts were undertaken to develop therapeutic approaches to …
(PD). Although extensive efforts were undertaken to develop therapeutic approaches to …
Proteostasis impairment in protein-misfolding and-aggregation diseases
Cells possess an extensive network of components to safeguard proteome integrity and
maintain protein homeostasis (proteostasis). When this proteostasis network (PN) declines …
maintain protein homeostasis (proteostasis). When this proteostasis network (PN) declines …