Azole-resistant Aspergillus fumigatus in the environment: Identifying key reservoirs and hotspots of antifungal resistance

C Burks, A Darby, L Gómez Londoño… - PLoS …, 2021 - journals.plos.org
Aspergillus fumigatus is an opportunistic human pathogen that causes aspergillosis, a
spectrum of environmentally acquired respiratory illnesses. It has a cosmopolitan distribution …

Antifungal therapy: new advances in the understanding and treatment of mycosis

L Scorzoni, ACA de Paula e Silva, CM Marcos… - Frontiers in …, 2017 - frontiersin.org
The high rates of morbidity and mortality caused by fungal infections are associated with the
current limited antifungal arsenal and the high toxicity of the compounds. Additionally …

[HTML][HTML] Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline

AJ Ullmann, JM Aguado, S Arikan-Akdagli… - Clinical Microbiology …, 2018 - Elsevier
Abstract The European Society for Clinical Microbiology and Infectious Diseases, the
European Confederation of Medical Mycology and the European Respiratory Society Joint …

Azole Resistance in Aspergillus fumigatus: Can We Retain the Clinical Use of Mold-Active Antifungal Azoles?

PE Verweij, A Chowdhary… - Clinical Infectious …, 2016 - academic.oup.com
Azole resistance in Aspergillus fumigatus has emerged as a global health problem.
Although the number of cases of azole-resistant aspergillosis is still limited, resistance …

Mechanisms of antifungal drug resistance

LE Cowen, D Sanglard… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Antifungal therapy is a central component of patient management for acute and chronic
mycoses. Yet, treatment choices are restricted because of the sparse number of antifungal …

Clinical implications of globally emerging azole resistance in Aspergillus fumigatus

JF Meis, A Chowdhary, JL Rhodes… - … of the Royal …, 2016 - royalsocietypublishing.org
Aspergillus fungi are the cause of an array of diseases affecting humans, animals and
plants. The triazole antifungal agents itraconazole, voriconazole, isavuconazole and …

Trends in agricultural triazole fungicide use in the United States, 1992–2016 and possible implications for antifungal-resistant fungi in human disease

M Toda, KD Beer, KM Kuivila, TM Chiller… - Environmental health …, 2021 - ehp.niehs.nih.gov
Background: The fungus Aspergillus fumigatus (A. fumigatus) is the leading cause of
invasive mold infections, which cause severe disease and death in immunocompromised …

Azole-resistant aspergillosis: epidemiology, molecular mechanisms, and treatment

A Chowdhary, C Sharma, JF Meis - The Journal of infectious …, 2017 - academic.oup.com
Aspergillus fumigatus remains the most common species in all pulmonary syndromes,
followed by Aspergillus flavus which is a common cause of allergic rhinosinusitis …

Emergence of Azole-Resistant Aspergillus fumigatus Strains due to Agricultural Azole Use Creates an Increasing Threat to Human Health

A Chowdhary, S Kathuria, J Xu, JF Meis - PLoS pathogens, 2013 - journals.plos.org
Aspergillus fumigatus, a ubiquitously distributed opportunistic pathogen, is the global
leading cause of aspergillosis and causes one of the highest numbers of deaths among …

Fungicide effects on human fungal pathogens: cross-resistance to medical drugs and beyond

RW Bastos, L Rossato, GH Goldman… - PLoS Pathogens, 2021 - journals.plos.org
Fungal infections are underestimated threats that affect over 1 billion people, and Candida
spp., Cryptococcus spp., and Aspergillus spp. are the 3 most fatal fungi. The treatment of …