Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase

A Nocentini, A Angeli, F Carta, JY Winum… - Journal of Enzyme …, 2021 - Taylor & Francis
Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) generally
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …

Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities

CT Supuran - Journal of Enzyme Inhibition and Medicinal …, 2022 - Taylor & Francis
The mitochondrial isoforms VA/VB of metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1)
are involved in metabolic processes, such as de novo lipogenesis and fatty acid …

Multi-and poly-pharmacology of carbonic anhydrase inhibitors

CT Supuran - Pharmacological Reviews, 2024 - Elsevier
Eight genetically distinct families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were
described in organisms allover the phylogenetic tree. They catalyze the hydration of CO 2 to …

Factors affecting flavor perception in space: Does the spacecraft environment influence food intake by astronauts?

AJ Taylor, JD Beauchamp, L Briand… - … reviews in food …, 2020 - Wiley Online Library
The intention to send a crewed mission to Mars involves a huge amount of planning to
ensure a safe and successful mission. Providing adequate amounts of food for the crew is a …

Sulphonamide inhibition studies of the β-carbonic anhydrase GsaCAβ present in the salmon platyhelminth parasite Gyrodactylus salaris

A Aspatwar, A Bonardi, H Aisala, K Zueva… - Journal of Enzyme …, 2023 - Taylor & Francis
A β-class carbonic anhydrase (CA, EC 4.2. 1.1) present in the genome of the Monogenean
platyhelminth Gyrodactylus salaris, a fish parasite, GsaCAβ, has been investigated for its …

Taste and Appetite at Altitude: A Comprehensive Review of Sensory and Hunger Modulation in High-Altitude Environments

JT Murphey, JL Temple, D Hostler - High Altitude Medicine & …, 2024 - liebertpub.com
Introduction: Individuals living or working at high altitudes typically experience altered taste
perceptions and reduced appetite. These changes can lead to nutritional deficiencies …

Sulfonamide Inhibition Studies of a New β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica

S Bua, S Haapanen, M Kuuslahti, S Parkkila… - International Journal of …, 2018 - mdpi.com
A newly described β-carbonic anhydrase (CA, EC 4.2. 1.1) from the pathogenic protozoan
Entamoeba histolytica, EhiCA, was recently shown to possess a significant catalytic activity …

Weight loss in idiopathic intracranial hypertension: a retrospective review of outcomes in the clinical setting

JL Ang, KZ Teo, CL Fraser - Journal of Neuro-Ophthalmology, 2021 - journals.lww.com
Background: Weight loss is important in the management of idiopathic intracranial
hypertension (IIH); however, extremely caloric restrictive diets have been used in published …

[HTML][HTML] Acetazolamide increases locomotion, exploratory behavior, and weight loss following social stress: A treatment for emotional eating?

R Woodman, J Student, T Malcolm, C Miller… - Metabolism Open, 2020 - Elsevier
Sympathomimetics are effective, centrally acting drugs that induce weight loss through their
potent anorexic and locomotor properties. We reported that sympathomimetics antagonize …

Hybrid Pharmacophores as Carbonic Anhydrase Inhibitors

S Bua - 2020 - flore.unifi.it
Carbonic anhydrases (CAs, EC 4.2. 1.1) are ubiquitous metalloenzymes encoded in most
organisms of the tree of life and classified in eight evolutionarily unrelated families: α-, β-, γ …