A century ago, Cajal noted striking similarities between the neural circuits that underlie
vision in vertebrates and flies. Over the past few decades, structural and functional studies …

The most impressive structural feature of the nervous system is the specificity of its synaptic
connections. Even after axons have navigated long distances to reach target areas, they …

Retinal ganglion cells (RGCs), which transfer information from the eye to the brain, are
heterogeneous in structure and function, but developmental studies have generally treated …

Transcriptional regulatory networks that control the morphologic and functional diversity of
mammalian neurons are still largely undefined. Here we dissect the roles of the highly …

The continuing worldwide epidemic of retinopathy of prematurity (ROP), a leading cause of
childhood visual impairment, strongly motivates further research into mechanisms of the …

Vision begins in the retina, whose intricate neural circuits extract salient features of the
environment from the light entering our eyes. Neurodegenerative diseases of the retina (eg …

The heterozygous mutation B6; C3-Opa1 Q285STOP, which models autosomal dominant
optic atrophy, leads to a 50% reduction in Opa1 transcript and protein in the mouse retina …

Retinal ganglion cell (RGC) death occurs in many eye diseases, such as glaucoma and
traumatic optic neuropathy (TON). Increasing evidence suggests that the susceptibility of …