Gene therapy is a technique involving the modification of an individual's genes for treating a
particular disease. The key to effective gene therapy is an efficient carrier delivery system …

Lentiviral vectors (LVs) are potent tools for the delivery of genes of interest into mammalian
cells and are now commonly utilised within the growing field of cell and gene therapy for the …

Extracellular vesicles (EVs) especially of mesenchymal stem/stomal cells (MSCs) are
increasingly considered as biotherapeutic agents for a variety of different diseases. For …

Replication defective vectors derived from simple retroviruses or the more complex
genomes of lentiviruses continue to offer the advantages of long-term expression, cell and …

From the perspective of a pilot clinical gene therapy trial for Wiskott–Aldrich syndrome
(WAS), we implemented a process to produce a lentiviral vector under good manufacturing …

Lentiviruses are becoming an increasingly popular choice of gene transfer vehicle for use in
the treatment of a variety of genetic and acquired human diseases. As research progresses …

Background HIV‐1‐derived vectors are promising tools for gene transfer into the brain.
Application of these vectors for gene therapy or for the creation of animal models for …

Virus-like particles (VLPs) offer great promise as candidates for new vaccine strategies.
Large-scale approaches for the manufacturing of HIV-1 Gag VLPs have mainly focused on …

Manufacturing of cell culture-derived virus particles for vaccination and gene therapy is a
rapidly growing field in the biopharmaceutical industry. The process involves a number of …

We have developed new packaging cell lines (293SF-PacLV) that can produce lentiviral
vectors (LVs) in serum-free suspension cultures. A cell line derived from 293SF cells …