Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …

Mitochondria are essential organelles with numerous functions in cellular metabolism and
homeostasis. Most of the> 1,000 different mitochondrial proteins are synthesized as …

Until recently, the dual roles of mitochondria in ATP production (bioenergetics) and
apoptosis (cell life/death decision) were thought to be separate. New evidence points to a …

Mitochondrial DNA instability disorders are responsible for a large clinical spectrum, among
which amyotrophic lateral sclerosis-like symptoms and frontotemporal dementia are …

Most, if not all mitochondrial functions, including adenosine-5′-triphosphate (ATP)
production and regulation of apoptosis and Ca 2+ homeostasis, are inextricably linked to …

Regions of close apposition between two organelles, often referred to as membrane contact
sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle …

Since it has been recognized that mitochondria are crucial not only for energy metabolism
but also for other cellular functions, there has been a growing interest in cardiolipin, the …

Mitochondria are complex organelles with two membranes. Their architecture is determined
by characteristic folds of the inner membrane, termed cristae. Recent studies in yeast and …

Mitochondria play central roles in cellular energetics, metabolism and signalling. Efficient
respiration, mitochondrial quality control, apoptosis and inheritance of mitochondrial DNA …

Mitochondrial functions are intrinsically linked to their morphology and membrane
ultrastructure. Characterizing abnormal mitochondrial structural features may thus provide …