Transmembrane β-barrel proteins of bacteria: from structure to function

S Hermansen, D Linke, JC Leo - Advances in Protein Chemistry and …, 2022 - Elsevier
The outer membrane of Gram-negative bacteria is a specialized organelle conferring
protection to the cell against various environmental stresses and resistance to many harmful …

Folding control in the path of type 5 secretion

N Dautin - Toxins, 2021 - mdpi.com
The type 5 secretion system (T5SS) is one of the more widespread secretion systems in
Gram-negative bacteria. Proteins secreted by the T5SS are functionally diverse (toxins …

BamA forms a translocation channel for polypeptide export across the bacterial outer membrane

MT Doyle, HD Bernstein - Molecular cell, 2021 - cell.com
The β-barrel assembly machine (BAM) integrates β-barrel proteins into the outer membrane
(OM) of Gram-negative bacteria. An essential BAM subunit (BamA) catalyzes integration by …

TamAB is regulated by PhoPQ and functions in outer membrane homeostasis during Salmonella pathogenesis

R Ramezanifard, YA Golubeva, AD Palmer… - Journal of …, 2023 - Am Soc Microbiol
Salmonella survive and replicate in macrophages, which normally kill bacteria by exposing
them to a variety of harsh conditions and antimicrobial effectors, many of which target the …

ATP‐independent assembly machinery of bacterial outer membranes: BAM complex structure and function set the stage for next‐generation therapeutics

A George, AG Patil, R Mahalakshmi - Protein Science, 2024 - Wiley Online Library
Diderm bacteria employ β‐barrel outer membrane proteins (OMPs) as their first line of
communication with their environment. These OMPs are assembled efficiently in the …

[HTML][HTML] Substrate-dependent arrangements of the subunits of the BAM complex determined by neutron reflectometry

X Chen, Y Ding, RS Bamert, AP Le Brun, AP Duff… - … et Biophysica Acta (BBA …, 2021 - Elsevier
In Gram-negative bacteria, the β-barrel assembly machinery (BAM) complex catalyses the
assembly of β-barrel proteins into the outer membrane, and is composed of five subunits …

Protein import and export across the bacterial outer membrane

J Guérin, SK Buchanan - Current opinion in structural biology, 2021 - Elsevier
The bacterial outer membrane forms an impermeable barrier to the environment, but a wide
variety of substances must cross it without compromising the membrane. Perhaps, the most …

Uncovering the folding mechanism of pertactin: A comparative study of isolated and vectorial folding

YT Pang, AJ Hazel, JC Gumbart - Biophysical Journal, 2023 - cell.com
Autotransporters are a large family of virulence factors found in Gram-negative bacteria that
play important roles in their pathogenesis. The passenger domain of autotransporters is …

Investigation of Key Mechanisms of Contact Dependent Growth Inhibition Systems in Burkholderia cepacia Complex Species

ZK Elery - 2023 - uknowledge.uky.edu
Burkholderia cepacia complex is a group of closely related environmental bacteria that can
exacerbate disease in immunocompromised individuals. B. cepacia bacteria are equipped …

Examining Protein Translocation by β-Barrel Membrane Proteins Using Reconstituted Proteoliposomes

MS Huynh, JC Xu, TF Moraes - … β-Barrel Proteins: Methods and Protocols, 2024 - Springer
Abstract β-barrel membrane proteins populate the outer membrane of Gram-negative
bacteria, mitochondria, and chloroplasts, playing significant roles in multiple key cellular …