A hallmark feature of tumorigenesis is uncontrolled cell division. Autophagy is regulated by
more than 30 genes and it is one of several mechanisms by which cells maintain …

The three members of the p160 family of steroid receptor coactivators (SRC-1, SRC-2, and
SRC-3) steer the functional output of numerous genetic programs and serve as pleiotropic …

About 250 million people worldwide are chronically infected with Hepatitis B virus (HBV),
contributing to a large burden on public health. Despite the existence of vaccines and …

High aerobic glycolysis not only provides energy to cancer cells, but also supports their
anabolic growth. JMJD1A, a histone demethylase that specifically demethylates …

Transcription of eukaryotic cell is a multistep process tightly controlled by concerted action of
macromolecules. Nuclear receptors are ligand-activated sequence-specific transcription …

HCC represents the sixth most common cancer worldwide and the second leading cause of
cancer-related death. Despite the high incidence, treatment options for advanced HCC …

The histone demethylase Jumonji domain containing 1A (JMJD1A) is overexpressed in
multiple tumors and promotes cancer progression. JMJD1A has been shown to promote …

Abstract BACKGROUND Lipocalin‐2 (LCN2) is a member of the lipocalin superfamily, and it
has an important role in the regulation of cellular oncogenesis and apoptosis. However, the …

Approximately 70% of breast cancers are estrogen receptor (ER)-positive and treated with
endocrine therapy. A commonly used treatment agent, tamoxifen, shows high efficacy for …

Steroid receptor coactivator-3 (SRC-3), also known as amplified in breast cancer 1 (AIB1), is
a member of the SRC family. SRC-3 regulates not only the transcriptional activity of nuclear …