Over the past two decades, new insights have positioned phosphoinositide 3-kinase-γ
(PI3Kγ) as a context-dependent modulator of immunity and inflammation. Recent advances …

Electrophilic compounds originating from nature or chemical synthesis have profound effects
on immune cells. These compounds are thought to act by cysteine modification to alter the …

Tyrosine kinases were first discovered as the protein products of viral oncogenes. We now
know that this large family of metazoan enzymes includes nearly one hundred structurally …

Summary Interleukin (IL)-2-inducible T cell kinase (ITK) is essential for T cell receptor (TCR)
signaling and plays an integral role in T cell proliferation and differentiation. Unlike the ITK …

CD8+ T cells play a critical role in adaptive immunity, differentiating into CD8+ memory T
cells that form the basis of protective cellular immunity. Vaccine efficacy is attributed to long …

The role of Bruton's tyrosine kinase (BTK) in BCR signaling is well defined, and BTK is
involved in B-cell development, differentiation, and malignancies. However, the expression …

The activation of T cells by the T cell antigen receptor (TCR) results in the formation of
signaling protein complexes (signalosomes), the composition of which has not been …

Interleukin-2-inducible T-cell kinase (ITK) regulates the response to T-cell receptor signaling
and is a drug target for inflammatory and immunological diseases. Molecules that bind …

Simple Summary Epstein–Barr Virus (EBV) is a common virus that is readily controlled by a
healthy immune system and rarely causes serious problems in infected people. However …

Treatment of patients with chronic lymphocytic leukemia (CLL) with inhibitors of Bruton's
tyrosine kinase (BTK), such as ibrutinib, is limited by primary or secondary resistance to this …