Abstract Denosumab (Prolia®; Pralia®) is a human monoclonal antibody targeting the key
bone resorption mediator RANKL. The drug is administered via subcutaneous injection once …

Fractures of the femoral neck can occur in young healthy individuals due to high loads
occurring during motor vehicle accidents, impacts, or falls. Failure forces are lower if impacts …

The surgeon general of the USA defines osteoporosis as “a skeletal disorder characterized
by compromised bone strength, predisposing to an increased risk of fracture.” Measuring …

Abstract Purpose of Review This study reviews the available literature to compare the
accuracy of areal bone mineral density derived from dual X-ray absorptiometry (DXA-aBMD) …

Osteoporotic fractures are a major clinical problem and current diagnostic tools have an
accuracy of only 50%. The aim of this study was to validate dual energy X-rays …

Finite element analysis (FEA) based on CT datasets of the spine or hip or on high-resolution
peripheral CT datasets of the distal forearm or tibia is now widely used in research and …

Microstructural and compositional changes that occur due to aging, pathological conditions,
or pharmacological treatments alter cortical bone fracture resistance. However, the relative …

Oestrogen deficiency-related bone loss in the ovariectomized (OVX) mouse is a common
model for osteoporosis. However, a comprehensive in vivo assessment of intervention …

High resolution peripheral quantitative computed tomography (HR-pQCT) provides methods
for quantifying volumetric bone mineral density and microarchitecture necessary for early …

Understanding bone mechanics at different hierarchical levels is fundamental to improve
preclinical and clinical assessments of bone strength. Digital Volume Correlation (DVC) is …