Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans
Compelling evidence for the inherited nature of essential hypertension has led to extensive
research in rats and humans. Rats have served as the primary model for research on the …
research in rats and humans. Rats have served as the primary model for research on the …
Genetic basis of polygenic hypertension
AY Deng - Human molecular genetics, 2007 - academic.oup.com
Essential hypertension is a common disorder that leads to significant morbidity and mortality;
however, the underlying mechanisms have remained elusive. Recent animal model studies …
however, the underlying mechanisms have remained elusive. Recent animal model studies …
Targeted disruption of Adamts16 gene in a rat genetic model of hypertension
A disintegrin-like metalloproteinase with thrombospondin motifs–16 (Adamts16) is an
important candidate gene for hypertension. The goal of the present study was to further …
important candidate gene for hypertension. The goal of the present study was to further …
Positional identification of variants of Adamts16 linked to inherited hypertension
A previously reported blood pressure (BP) quantitative trait locus on rat Chromosome 1 was
isolated in a short congenic segment spanning 804.6 kb. The 804.6 kb region contained …
isolated in a short congenic segment spanning 804.6 kb. The 804.6 kb region contained …
Dietary salt regulates renal SGK1 abundance: relevance to salt sensitivity in the Dahl rat
Serum and glucocorticoid-induced kinase 1 (SGK1) activates the epithelial sodium channel
(eNaC) in tubules. We examined renal SGK1 abundance in salt-adaptation and in salt …
(eNaC) in tubules. We examined renal SGK1 abundance in salt-adaptation and in salt …
Beyond the gastrointestinal tract: oral and sex-specific skin microbiota are associated with hypertension in rats with genetic disparities
Current knowledge of the link between microbiota and hypertension is limited to the gut.
Besides the gut, oral cavity and skin are other locations where sodium chloride (NaCl) is in …
Besides the gut, oral cavity and skin are other locations where sodium chloride (NaCl) is in …
Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats
MR Garrett, JP Rapp - Physiological genomics, 2002 - journals.physiology.org
Previously we reported the construction of a congenic strain, S. LEW, spanning a large
region of rat chromosome 5. The Lewis (LEW) strain was the donor, and the Dahl salt …
region of rat chromosome 5. The Lewis (LEW) strain was the donor, and the Dahl salt …
Locating a blood pressure quantitative trait locus within 117 kb on the rat genome: substitution map** and renal expression analysis
Previously, a blood pressure (BP) quantitative trait locus (QTL) on rat chromosome 9 (RNO9)
was localized to a< 2.4 cM interval using congenic strains generated by introgressing …
was localized to a< 2.4 cM interval using congenic strains generated by introgressing …
Positional cloning of quantitative trait Loci for blood pressure: how close are we? a critical perspective
AY Deng - Hypertension, 2007 - Am Heart Assoc
Hypertensive individuals are those whose BP is maintained at one extreme of the curve and
above a defined cutoff. Despite progress made in identifying the mechanisms underlying …
above a defined cutoff. Despite progress made in identifying the mechanisms underlying …
Rats with inherited stress‐induced arterial hypertension (ISIAH strain) display specific quantitative trait loci for blood pressure and for body and kidney weight on …
OE Redina, NA Machanova, VM Efimov… - Clinical and …, 2006 - Wiley Online Library
SUMMARY 1 The aim of the present study was to scan chromosome 1 in the hypertensive
'inherited stress‐induced arterial hypertension'(ISIAH) rat strain for the quantitative trait loci …
'inherited stress‐induced arterial hypertension'(ISIAH) rat strain for the quantitative trait loci …