Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …

Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell
receptor (TCR) ligation for naive T cell activation. Here, we discuss the expression, structure …

The intestine is a complex organ that promotes digestion, extracts nutrients, participates in
immune surveillance, maintains critical symbiotic relationships with microbiota and affects …

Tumor-associated macrophages are transcriptionally heterogeneous, but the spatial
distribution and cell interactions that shape macrophage tissue roles remain poorly …

The regulation of antibody production is linked to the generation and maintenance of
plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly …

Antibody responses to viral infections are sustained for decades by long-lived plasma cells
(LLPCs). However, LLPCs have yet to be characterized in humans. Here we used CD19 …

Therapeutic targeting of immune checkpoints has garnered significant attention in the area
of cancer immunotherapy, in which efforts have focused in particular on cytotoxic T …

It is now well accepted that plasma cells can become long-lived (memory) plasma cells and
secrete antibodies for months, years or a lifetime. However, the mechanisms involved in this …

Durable humoral immunity is dependent upon the generation of antigen-specific antibody
titers, produced by non-proliferating bone marrow resident long-lived plasma cells (LLPC) …

Avoiding immune destruction is a hallmark of cancer. Over the past few years, significant
advances have been made in understanding immune dysfunction and immunosuppression …