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[HTML][HTML] Cell-penetrating peptide-based delivery of macromolecular drugs: development, strategies, and progress
Cell-penetrating peptides (CPPs), developed for more than 30 years, are still being
extensively studied due to their excellent delivery performance. Compared with other …
extensively studied due to their excellent delivery performance. Compared with other …
[HTML][HTML] Polysaccharides-based injectable hydrogels: Preparation, characteristics, and biomedical applications
Polysaccharides-based injectable hydrogels are a unique group of biodegradable and
biocompatible materials that have shown great potential in the different biomedical fields …
biocompatible materials that have shown great potential in the different biomedical fields …
A cathepsin B/GSH dual-responsive fluorinated peptide for effective siRNA delivery to cancer cells
Small interfering RNA (siRNA) can be exploited to silence specific genes associated with
cancer development, and successful siRNA therapy is highly dependent on the efficiency of …
cancer development, and successful siRNA therapy is highly dependent on the efficiency of …
A straightforward method for the development of positively charged gold nanoparticle-based vectors for effective siRNA delivery
TN Elizarova, ML Antopolsky, DO Novichikhin… - Molecules, 2023 - mdpi.com
The therapeutic potential of short interfering RNA (siRNA) to treat many diseases that are
incurable with traditional preparations is limited by the extensive metabolism of serum …
incurable with traditional preparations is limited by the extensive metabolism of serum …
Cell-Penetrating Peptides in infection and immunization
Bacteria and viruses pose significant threats to human health, as drug molecules and
therapeutic agents are often hindered by cell membranes and tissue barriers from reaching …
therapeutic agents are often hindered by cell membranes and tissue barriers from reaching …
Poly (A) Tail Length of Messenger RNA Regulates Translational Efficiency of the Mitochondria-Targeting Delivery System
Mitochondria are essential for cellular functions, such as energy production. Human
mitochondrial DNA (mtDNA), encoding 13 distinct genes, two rRNA, and 22 tRNA, is crucial …
mitochondrial DNA (mtDNA), encoding 13 distinct genes, two rRNA, and 22 tRNA, is crucial …
[HTML][HTML] An amphipathic structure of a dipropylglycine-containing helical peptide with sufficient length enables safe and effective Intracellular siRNA delivery
Amphipathic peptides composed of cationic amino acids and hydrophobic amino acids have
cell-penetrating ability and are often used as a delivery tool for membrane-impermeable …
cell-penetrating ability and are often used as a delivery tool for membrane-impermeable …
[HTML][HTML] Design, synthesis, and evaluation of Oleyl-WRH peptides for siRNA delivery
Delivering nucleic acid therapeutics across cell membranes is a significant challenge. Cell-
penetrating peptides (CPPs) containing arginine (R), tryptophan (W), and histidine (H) show …
penetrating peptides (CPPs) containing arginine (R), tryptophan (W), and histidine (H) show …
[HTML][HTML] Targeting pediatric solid tumors in the new era of RNA therapeutics
Despite substantial progress in pediatric cancer treatment, poor prognosis remained for
patients with recurrent or metastatic disease, given the limitations of approved targeted …
patients with recurrent or metastatic disease, given the limitations of approved targeted …
Modified Linear Peptides Effectively Silence STAT-3 in Breast Cancer and Ovarian Cancer Cell Lines
RNA interference (RNAi) has drawn enormous attention as a powerful tool because of its
capability to interfere with mRNA and protein production. However, designing a safe and …
capability to interfere with mRNA and protein production. However, designing a safe and …