Cardiovascular disease is the leading cause of death, medical complications, and
healthcare costs. Although recent advances have been in treating cardiovascular disorders …

Background and aim Klotho was first identified as a gene associated with aging and
longevity in 1997. α-Klotho is an anti-aging protein and its role in energy metabolism …

Regular exercise training has potent and powerful protective effects against the
development of cardiovascular disease. These cardioprotective effects of regular exercise …

(1) Background: Years of research have identified ischemic preconditioning (IPC) as a
crucial endogenous protective mechanism against myocardial ischemia–reperfusion injury …

Ischemia/reperfusion injury (IRI) of the heart involves the activation of oxidative and
proapoptotic pathways. Simultaneously Klotho protein presents anti-aging, antiapoptotic and …

Sarcopenia and impaired cardiorespiratory fitness are commonly observed in older
individuals and patients with chronic kidney disease (CKD). Declines in skeletal muscle …

Thyroid hormones are critical for healthy brain functions at every stage of life.
Hypothyroidism can cause severe cognitive dysfunction in patients who do not receive …

Mild to moderate-intensity endurance exercise training combined with hind-limb blood flow
restriction (BFR) induces elderly heart rejuvenation and improves cardiac inotropy and …

The formation of new blood vessels in the ischemic area is a fundamental strategy that can
reduce myocardial infarction-induced damage by mitigating hypoxia. This paper set out to …

Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic
disorders. This study aimed to investigate the effects of high-intensity interval training (HIIT) …