Current advance of nanotechnology in diagnosis and treatment for malignant tumors

B Wang, S Hu, Y Teng, J Chen, H Wang, Y Xu… - … and Targeted Therapy, 2024 - nature.com
Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …

Label-free microfluidic cell sorting and detection for rapid blood analysis

N Lu, HM Tay, C Petchakup, L He, L Gong, KK Maw… - Lab on a Chip, 2023 - pubs.rsc.org
Blood tests are considered as standard clinical procedures to screen for markers of diseases
and health conditions. However, the complex cellular background (> 99.9% RBCs) and …

Single-cell microfluidic impedance cytometry: From raw signals to cell phenotypes using data analytics

C Honrado, P Bisegna, NS Swami, F Caselli - Lab on a Chip, 2021 - pubs.rsc.org
The biophysical analysis of single-cells by microfluidic impedance cytometry is emerging as
a label-free and high-throughput means to stratify the heterogeneity of cellular systems …

Neural network-enhanced real-time impedance flow cytometry for single-cell intrinsic characterization

Y Feng, Z Cheng, H Chai, W He, L Huang, W Wang - Lab on a Chip, 2022 - pubs.rsc.org
Single-cell impedance flow cytometry (IFC) is emerging as a label-free and non-invasive
method for characterizing the electrical properties and revealing sample heterogeneity. At …

Positional dependence of particles and cells in microfluidic electrical impedance flow cytometry: Origin, challenges and opportunities

H Daguerre, M Solsona, J Cottet, M Gauthier… - Lab on a Chip, 2020 - pubs.rsc.org
Microfluidic electrical impedance flow cytometry is now a well-known and established
method for single-cell analysis. Given the richness of the information provided by impedance …

Automated biophysical classification of apoptotic pancreatic cancer cell subpopulations by using machine learning approaches with impedance cytometry

C Honrado, A Salahi, SJ Adair, JH Moore, TW Bauer… - Lab on a Chip, 2022 - pubs.rsc.org
Unrestricted cell death can lead to an immunosuppressive tumor microenvironment, with
dysregulated apoptotic signaling that causes resistance of pancreatic cancer cells to …

Microfluidic impedance‐deformability cytometry for label‐free single neutrophil mechanophenoty**

C Petchakup, H Yang, L Gong, L He, HM Tay, R Dalan… - Small, 2022 - Wiley Online Library
The intrinsic biophysical states of neutrophils are associated with immune dysfunctions in
diseases. While advanced image‐based biophysical flow cytometers can probe cell …

Microfluidic impedance cytometry for single-cell sensing: Review on electrode configurations

S Zhu, X Zhang, Z Zhou, Y Han, N **ang, Z Ni - Talanta, 2021 - Elsevier
Single-cell analysis has gained considerable attention for disease diagnosis, drug
screening, and differentiation monitoring. Compared to the well-established flow cytometry …

Modified red blood cells as multimodal standards for benchmarking single-cell cytometry and separation based on electrical physiology

A Salahi, C Honrado, A Rane, F Caselli… - Analytical …, 2022 - ACS Publications
Biophysical cellular information at single-cell sensitivity is becoming increasingly important
within analytical and separation platforms that associate the cell phenotype with markers of …

A neural network approach for real-time particle/cell characterization in microfluidic impedance cytometry

C Honrado, JS McGrath, R Reale, P Bisegna… - Analytical and …, 2020 - Springer
Microfluidic applications such as active particle sorting or selective enrichment require
particle classification techniques that are capable of working in real time. In this paper, we …