Supramolecular DNA recognition

MJ Hannon - Chemical Society Reviews, 2007 - pubs.rsc.org
Non-covalent DNA-recognition by synthetic agents is surveyed in this tutorial review, and
contrasted with biomolecular DNA-recognition. The principles and forces involved in DNA …

Interactions of small molecules with DNA junctions

KT McQuaid, A Pipier, CJ Cardin… - Nucleic Acids …, 2022 - academic.oup.com
The four natural DNA bases (A, T, G and C) associate in base pairs (A= T and G≡ C),
allowing the attached DNA strands to assemble into the canonical double helix of DNA (or …

[BOOK][B] Nucleic acids in chemistry and biology

GM Blackburn - 2006 - books.google.com
The structure, function and reactions of nucleic acids are central to molecular biology and
are crucial for the understanding of complex biological processes involved. Revised and …

[HTML][HTML] Major achievements in the design of quadruplex-interactive small molecules

E Mendes, IM Aljnadi, B Bahls, BL Victor, A Paulo - Pharmaceuticals, 2022 - mdpi.com
Organic small molecules that can recognize and bind to G-quadruplex and i-Motif nucleic
acids have great potential as selective drugs or as tools in drug target discovery programs …

Targeting DNA junction sites by bis-intercalators induces topological changes with potent antitumor effects

SC Huang, CW Chen, R Satange… - Nucleic Acids …, 2024 - academic.oup.com
Targeting inter-duplex junctions in catenated DNA with bidirectional bis-intercalators is a
potential strategy for enhancing anticancer effects. In this study, we used d (CGTATACG) 2 …

Non-G base tetrads

N Escaja, B Mir, M Garavís, C González - Molecules, 2022 - mdpi.com
Tetrads (or quartets) are arrangements of four nucleobases commonly involved in the
stability of four-stranded nucleic acids structures. Four-stranded or quadruplex structures …

DNA and the chromosome–varied targets for chemotherapy

SM Nelson, LR Ferguson, WA Denny - Cell & chromosome, 2004 - Springer
The nucleus of the cell serves to maintain, regulate, and replicate the critical genetic
information encoded by the genome. Genomic DNA is highly associated with proteins that …

Ligand Bridging of the DNA Holliday Junction: Molecular Recognition of a Stacked‐X Four‐Way Junction by a Small Molecule

AL Brogden, NH Hopcroft, M Searcey… - Angewandte Chemie …, 2007 - Wiley Online Library
Homologous recombination (HR) in the repair of a collapsed replication fork is a process
that involves strand invasion, branch migration, and resolution of the resulting Holliday …

Assessing the differential affinity of small molecules for noncanonical DNA structures

L Stefan, B Bertrand, P Richard, P Le Gendre… - …, 2012 - Wiley Online Library
The targeting of higher‐order DNA structures has been thoroughly developed with G‐
quadruplex DNA but not with other structures like branched DNA (also known as DNA …

Thread Insertion of a Bis (dipyridophenazine) Diruthenium Complex into the DNA Double Helix by the Extrusion of AT Base Pairs and Cross‐Linking of DNA Duplexes

DR Boer, L Wu, P Lincoln, M Coll - Angewandte Chemie, 2014 - Wiley Online Library
The crystal structure of the Δ, Δ enantiomer of the binuclear “light‐switch” ruthenium complex
[μ‐(11, 11′‐bidppz)(1, 10‐phenanthroline) 4 Ru2] 4+ bound to the oligonucleotide d …