Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), and
astrocytes constitute macroglia. This review deals with the recent progress related to the …

Nogo-A is one of several neurite growth inhibitory components present in oligodendrocytes
and CNS myelin membranes. Nogo has a crucial role in restricting axonal regeneration and …

The capacity of the adult brain and spinal cord to repair lesions by axonal regeneration or
compensatory fibre growth is extremely limited. A monoclonal antibody (IN-1) raised against …

Adult mammalian axon regeneration is generally successful in the peripheral nervous
system (PNS) but is dismally poor in the central nervous system (CNS). However, many …

The inhibitory activity associated with myelin is a major obstacle for successful axon
regeneration in the adult mammalian central nervous system (CNS),. In addition to myelin …

Axons are generally believed to be incapable of regeneration in the adult central nervous
system,. Inhibition results from physical barriers imposed by glial scars, a lack of …

Nogo-A is a neurite growth inhibitor involved in regenerative failure and restriction of
structural plasticity in the adult CNS. Three major protein products (Nogo-A,-B, and-C) are …

Nogo-A is a potent neurite growth inhibitor in vitro and plays a role both in the restriction of
axonal regeneration after injury and in structural plasticity in the CNS of higher vertebrates …

To investigate the role of the myelin-associated protein Nogo-A on axon sprouting and
regeneration in the adult central nervous system (CNS), we generated Nogo-A-deficient …

Spinal cord trauma leads to loss of motor, sensory and autonomic functions below the
lesion. Recovery is very restricted, due in part to neurite growth inhibitory myelin proteins, in …