Responding to tissue injury, skeletal muscles undergo the tissue destruction and
reconstruction accompanied with inflammation. The immune system recognizes the …

Diabetes represents a major public health concern with a considerable impact on human life
and healthcare expenditures. It is now well established that diabetes is characterized by a …

Macrophage senescence, manifested by the special form of durable cell cycle arrest and
chronic low-grade inflammation like senescence-associated secretory phenotype, has long …

Skeletal muscle aging is a key contributor to age-related frailty and sarcopenia with
substantial implications for global health. Here we profiled 90,902 single cells and 92,259 …

Inclusion body myositis (IBM) is the most prevalent inflammatory muscle disease in older
adults with no effective therapy available. In contrast to other inflammatory myopathies such …

Skeletal muscle is essential for body physical activity, energy metabolism, and temperature
maintenance. It has excellent capabilities to maintain homeostasis and to regenerate after …

Aging is associated with profound alterations in skeletal muscle, including loss of muscle
mass and function, local inflammation, altered mitochondrial physiology, and attenuated …

Tissue fibrosis affects multiple organs and involves a master-regulatory role of macrophages
which respond to an initial inflammatory insult common in all forms of fibrosis. The recently …

Adult tissue-resident macrophages (RMs) are either maintained by blood monocytes or
through self-renewal. While the presence of a nurturing niche is likely crucial to support the …

The skeletal muscle is a dynamic organ composed of contractile muscle fibers, connective
tissues, blood vessels and nerve endings. Its main function is to provide motility to the body …