DNA replication timing

N Rhind, DM Gilbert - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
Patterns of replication within eukaryotic genomes correlate with gene expression, chromatin
structure, and genome evolution. Recent advances in genome-scale map** of replication …

Stochastic mechano-chemical kinetics of molecular motors: a multidisciplinary enterprise from a physicist's perspective

D Chowdhury - Physics Reports, 2013 - Elsevier
A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …

Genome-wide map** of human DNA replication by optical replication map** supports a stochastic model of eukaryotic replication

W Wang, KN Klein, K Proesmans, H Yang, C Marchal… - Molecular cell, 2021 - cell.com
The heterogeneous nature of eukaryotic replication kinetics and the low efficiency of
individual initiation sites make map** the location and timing of replication initiation in …

Modeling genome‐wide replication kinetics reveals a mechanism for regulation of replication timing

SCH Yang, N Rhind, J Bechhoefer - Molecular systems biology, 2010 - embopress.org
Microarrays are powerful tools to probe genome‐wide replication kinetics. The rich data sets
that result contain more information than has been extracted by current methods of analysis …

A chromatin structure‐based model accurately predicts DNA replication timing in human cells

Y Gindin, MS Valenzuela, MI Aladjem… - Molecular systems …, 2014 - embopress.org
The metazoan genome is replicated in precise cell lineage‐specific temporal order.
However, the mechanism controlling this orchestrated process is poorly understood as no …

Replication timing and its emergence from stochastic processes

J Bechhoefer, N Rhind - Trends in Genetics, 2012 - cell.com
The temporal organization of DNA replication has puzzled cell biologists since before the
mechanism of replication was understood. The realization that replication timing correlates …

Mathematical modelling of whole chromosome replication

APS de Moura, R Retkute, M Hawkins… - Nucleic acids …, 2010 - academic.oup.com
All chromosomes must be completely replicated prior to cell division, a requirement that
demands the activation of a sufficient number of appropriately distributed DNA replication …

[KİTAP][B] Embryogenesis explained

NK Gordon, R Gordon - 2016 - books.google.com
The greatest mystery of life is how a single fertilized egg develops into a fully functioning,
sometimes conscious multicellular organism. Embryogenesis Explained offers a new theory …

DNA replication timing: Biochemical mechanisms and biological significance

N Rhind - BioEssays, 2022 - Wiley Online Library
The regulation of DNA replication is a fascinating biological problem both from a
mechanistic angle—How is replication timing regulated?—and from an evolutionary one …

Reconciling stochastic origin firing with defined replication timing

N Rhind, SCH Yang, J Bechhoefer - Chromosome Research, 2010 - Springer
Eukaryotic chromosomes replicate with defined timing patterns. However, the mechanism
that regulates the timing of replication is unknown. In particular, there is an apparent conflict …