Mutations in genes affecting endocrine signaling, stress responses, metabolism, and
telomeres can all increase the life spans of model organisms. These mutations have …

Lipids play crucial roles in regulating aging and longevity. In the past few decades, a series
of genetic pathways have been discovered to regulate lifespan in model organisms …

The life span of C. elegans can be increased via reduced function of the mitochondria;
however, the extent to which mitochondrial alteration in a single, distinct tissue may …

The nematode Caenorhabditis elegans is an important model for studying the genetics of
ageing, with over 50 life-extension mutations known so far. However, little is known about …

Summary Insulin/IGF-1-like signaling (IIS) is central to growth and metabolism and has a
conserved role in aging. In C. elegans, reductions in IIS increase stress resistance and …

Many conditions that shift cells from states of nutrient utilization and growth to states of cell
maintenance extend lifespan. We have carried out a systematic lifespan analysis of …

Recent advances in metabolomics and computational analysis have deepened our
appreciation for the role of specific metabolic pathways in dictating cell fate. Once thought to …

Chromatin modifiers regulate lifespan in several organisms, raising the question of whether
changes in chromatin states in the parental generation could be incompletely …

In C. elegans, the transcription factor DAF-16 promotes longevity in response to reduced
insulin/IGF-1 signaling or germline ablation. In this study, we have asked how different …

Several factors (the lengthening of the average and, to a lesser extent, of the maximum
human life span; the increase in percentage of elderly in the population and in the …