Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …

The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …

Neutrophils are the most abundant myeloid cells in human blood and are emerging as
important regulators of cancer. However, their functional importance has often been …

Heterogeneity within a tumour increases its ability to adapt to constantly changing
constraints, but adversely affects a patient's prognosis, therapy response and clinical …

Cancer cell identity and plasticity are required in transition states, such as epithelial–
mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET), in primary …

Epithelial-mesenchymal transition (EMT) is a cellular process by which epithelial cells lose
their characteristics and acquire mesenchymal traits to promote cell movement. This …

Triple-negative breast cancer (TNBC) is an aggressive subtype associated with early
metastatic recurrence and worse patient outcomes. TNBC tumors express molecular …

Epithelial stem cells serve critical physiological functions in the generation, maintenance
and repair of diverse tissues through their ability to self-renew and spawn more specialized …

Inflammation predisposes to the development of cancer and promotes all stages of
tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage …

Breast cancer is one of the most common malignancies among women throughout the world
and is the major cause of most cancer-related deaths. Several explanations account for the …