Amorphous solid dispersions (ASDs) are among the most popular and widely studied
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …

The prevalence of active pharmaceutical ingredients (APIs) with low water solubility has
experienced a significant increase in recent years. These APIs present challenges in …

As the advancements in the medical technology and healthcare develop through the years,
combinational therapy has evolved to be an important treatment modality in many disease …

This study aims to investigate the potential use of polymer inclusion in the phospholipid-
based solid dispersion approach for augmenting the biopharmaceutical performance of …

Valsartan (VAL) is a BCS class II drug with low solubility and high permeability and, thus, its
formulations often encounter low bioavailability problems. Its low bioavailability can be …

The development of amorphous solid dispersions (ASD) is one way to overcome the
bioavailability challenges of poorly water-soluble drug. Herein, Curcumin (CUR) was …

Curcumin is a turmeric-derived bioactive flavonoid that is beneficial to human health.
Unfortunately, poor water solubility and low bioactivity of curcumin limit its applications …

The study aimed to address the challenges related to insufficient dissolution and
maintenance of supersaturation in binary solid dispersions. Lacidipine, categorized as a …

Phytosterols (PS) offer significant health benefits in human diet, but its poor solubility limits
its effectiveness and application. This study explored enhancing PS solubility by testing …

The present investigation aimed to enhance the oral bioavailability of the poorly water-s
Glibenclamide (GLB) using amorphous solid dispersions (ASD) with various polymers. The …