Alcohol consumption and stress increase brain levels of known innate immune signaling
molecules. Microglia, the innate immune cells of the brain, and neurons respond to alcohol …

Addiction is a worldwide public health problem and this article reviews scientific advances in
identifying the role of neuroinflammation in the genesis, maintenance, and treatment of …

Drug addiction is a chronic and debilitating disease that is considered a global health
problem. Various cell types in the brain are involved in the progression of drug addiction …

Epidemiological studies suggest that heavy alcohol use early in life is associated with
increased risk for Alzheimer's disease (AD). However, mechanisms connecting AD with …

Recent studies examining the neurobiology of substance abuse have revealed a significant
role of neuroimmune signaling as a mechanism through which drugs of abuse induce …

Background and purpose Minocycline is a broad‐spectrum antibiotic, effective as a chronic
treatment for recurrent bacterial infections. Beyond its antibiotic action, minocycline also has …

Innate immune signaling is an important feature in the pathology of alcohol use disorders.
Alcohol abuse causes persistent innate immune activation in the brain. This is seen in …

Substance use disorders are global health problems with few effective treatment options.
Unfortunately, most potential pharmacological treatments are hindered by abuse potential of …

Methamphetamine (METH) addiction is a significant public health issue, and standard
medical therapies are often not curative. Deep Brain Stimulation (DBS) has recently shown …

Methamphetamine use disorder (MUD) is a chronic, relapsing disease that is characterized
by repeated drug use despite negative consequences and for which there are currently no …