The evolutionary and functional significance of germline immunoglobulin gene variation
The recombination between immunoglobulin (IG) gene segments determines an individual's
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …
Idiosyncratic epistasis leads to global fitness–correlated trends
Epistasis can markedly affect evolutionary trajectories. In recent decades, protein-level
fitness landscapes have revealed extensive idiosyncratic epistasis among specific …
fitness landscapes have revealed extensive idiosyncratic epistasis among specific …
Co-evolution of interacting proteins through non-contacting and non-specific mutations
Proteins often accumulate neutral mutations that do not affect current functions but can
profoundly influence future mutational possibilities and functions. Understanding such …
profoundly influence future mutational possibilities and functions. Understanding such …
Insights into next generation sequencing guided antibody selection strategies
Therapeutic antibody discovery often relies on in-vitro display methods to identify lead
candidates. Assessing selected output diversity traditionally involves random colony picking …
candidates. Assessing selected output diversity traditionally involves random colony picking …
Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies
Over the past two decades, several broadly neutralizing antibodies (bnAbs) that confer
protection against diverse influenza strains have been isolated. Structural and biochemical …
protection against diverse influenza strains have been isolated. Structural and biochemical …
Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site
The HIV-1 fusion peptide (FP) represents a promising vaccine target, but global FP
sequence diversity among circulating strains has limited anti-FP antibodies to~ 60 …
sequence diversity among circulating strains has limited anti-FP antibodies to~ 60 …
Large-scale antibody immune response map** of splenic B cells and bone marrow plasma cells in a transgenic mouse model
X Pan, SN López Acevedo, C Cuziol… - Frontiers in …, 2023 - frontiersin.org
Molecular characterization of antibody immunity and human antibody discovery is mainly
carried out using peripheral memory B cells, and occasionally plasmablasts, that express B …
carried out using peripheral memory B cells, and occasionally plasmablasts, that express B …
An optimized thermodynamics integration protocol for identifying beneficial mutations in antibody design
Accurate identification of beneficial mutations is central to antibody design. Many knowledge-
based (KB) computational approaches have been developed to predict beneficial mutations …
based (KB) computational approaches have been developed to predict beneficial mutations …
Molecular probes of spike ectodomain and its subdomains for SARS-CoV-2 variants, Alpha through Omicron
Since the outbreak of the COVID-19 pandemic, widespread infections have allowed SARS-
CoV-2 to evolve in human, leading to the emergence of multiple circulating variants. Some …
CoV-2 to evolve in human, leading to the emergence of multiple circulating variants. Some …
Map** monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged
continuously, challenging the effectiveness of vaccines, diagnostics, and treatments …
continuously, challenging the effectiveness of vaccines, diagnostics, and treatments …