Biopharmaceutics Classification System (BCS) Class II and IV drugs suffer from poor
aqueous solubility and hence low bioavailability. Most of these drugs are hydrophobic and …

Poor bioavailability and aqueous solubility represent a major constraint during the
development of new API molecules and can influence the impact of new medicines or halt …

Cocrystals are long known yet recently applied molecular entities. In the past decade, a
significant potential has been demonstrated by these novel solids in terms of modifying the …

Polymorphism in crystals is known since 1822 and the credit goes to Mitscherlich who
realized the existence of different crystal structures of the same compound while working …

We present SpeedMixing, a rapid blending technology, as an approach for fast
mechanosynthesis and discovery of model pharmaceutical cocrystals through rapid …

The antiepilepsy drug carbamazepine is one of the most studied pharmaceuticals in the
world. The rich story of its solid forms, cocrystals, and formulation is a microcosm of the …

Polymorphism can be a valuable tool as well as an impediment in the development and
approval of pharmaceuticals, providing an opportunity to tune active pharmaceutical …

This work aims to evaluate the effect of polymorphism on the physicochemical properties of
meloxicam, which is an antipyretic and non-steroidal anti-inflammatory drug. Powder X-ray …

This article describes the synthesis and characterization of new cocrystals of ciprofloxacin
with nicotinic and isonicotinic acids as coformers. The cocrystals were obtained by a …

Baicalein (BE) is a flavonoid compound derived from the roots of Scutellaria baicalensis. It
has widely been used as anti-oxidant, anti-virus, anti-bacteria, anti-inflammatory and anti …