Targeting circular RNAs as a therapeutic approach: current strategies and challenges
Significant progress has been made in circular RNA (circRNA) research in recent years.
Increasing evidence suggests that circRNAs play important roles in many cellular processes …
Increasing evidence suggests that circRNAs play important roles in many cellular processes …
CircRNAs: role in human diseases and potential use as biomarkers
L Verduci, E Tarcitano, S Strano, Y Yarden… - Cell death & …, 2021 - nature.com
Circular RNAs (circRNAs) are a class of endogenous RNAs characterized by a covalent
loop structure. In comparison to other types of RNAs, the abundance of circRNAs is relatively …
loop structure. In comparison to other types of RNAs, the abundance of circRNAs is relatively …
Circular RNA: An emerging frontier in RNA therapeutic targets, RNA therapeutics, and mRNA vaccines
Circular RNAs (circRNA) is a class of natural (biogenic) or synthetic closed RNA without 5′
or 3′ ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA …
or 3′ ends. Meanwhile, their unique covalently-closed structures of circRNA prevent RNA …
The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer
X Zheng, M Huang, L **ng, R Yang, X Wang, R Jiang… - Molecular cancer, 2020 - Springer
Background Increasing studies have shown that circRNA is closely related to the
carcinogenesis and development of many cancers. However, biological functions and the …
carcinogenesis and development of many cancers. However, biological functions and the …
Going circular: history, present, and future of circRNAs in cancer
To date, thousands of highly abundant and conserved single-stranded RNA molecules
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …
shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional …
Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit
C Ma, X Wang, F Yang, Y Zang, J Liu, X Wang, X Xu… - Molecular cancer, 2020 - Springer
Background Emerging evidence has shown that circular RNAs (circRNAs) play a crucial
regulatory role in the occurrence and development of cancer. Exploring the roles and …
regulatory role in the occurrence and development of cancer. Exploring the roles and …
circRNA-miRNA-mRNA in breast cancer
M Zhang, X Bai, X Zeng, J Liu, F Liu, Z Zhang - Clinica Chimica Acta, 2021 - Elsevier
Among cancers, breast cancer has the highest incidence rate among women and poses a
tremendous threat to women's health. Messenger RNA (mRNA), microRNA (miRNA) and …
tremendous threat to women's health. Messenger RNA (mRNA), microRNA (miRNA) and …
Circular RNAs: biogenesis, mechanism, and function in human cancers
X Zhao, Y Cai, J Xu - International journal of molecular sciences, 2019 - mdpi.com
CircRNAs are a class of noncoding RNA species with a circular configuration that is formed
by either typical spliceosome-mediated or lariat-type splicing. The expression of circRNAs is …
by either typical spliceosome-mediated or lariat-type splicing. The expression of circRNAs is …
Hsa_circ_0060467 promotes breast cancer liver metastasis by complexing with eIF4A3 and sponging miR-1205
Y Zeng, W Du, Z Huang, S Wu, X Ou, J Zhang… - Cell death …, 2023 - nature.com
Breast cancer (BC) is the most common cancer and the top cause of female mortality
worldwide. The prognosis for patients with breast cancer liver metastasis (BCLM) remains …
worldwide. The prognosis for patients with breast cancer liver metastasis (BCLM) remains …
Biological roles and mechanisms of circular RNA in human cancers
Q Tang, SS Hann - OncoTargets and therapy, 2020 - Taylor & Francis
Circular RNA (circRNA) is an intriguing class of RNA with covalently closed-loop structure
and is highly stable and conservative. As new members of the ncRNAs, the function …
and is highly stable and conservative. As new members of the ncRNAs, the function …