Airway remodeling in asthma: what really matters
Airway remodeling is generally quite broadly defined as any change in composition,
distribution, thickness, mass or volume and/or number of structural components observed in …
distribution, thickness, mass or volume and/or number of structural components observed in …
Mouse models of allergic asthma: acute and chronic allergen challenge
AT Nials, S Uddin - Disease models & mechanisms, 2008 - journals.biologists.com
Asthma is defined as a chronic inflammatory disease of the airways; however, the underlying
physiological and immunological processes are not fully understood. Animal models have …
physiological and immunological processes are not fully understood. Animal models have …
Bidirectional interaction of airway epithelial remodeling and inflammation in asthma
Asthma is a chronic disease of the airways that has long been viewed predominately as an
inflammatory condition. Accordingly, current therapeutic interventions focus primarily on …
inflammatory condition. Accordingly, current therapeutic interventions focus primarily on …
Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
Exaggerated levels of VEGF (vascular endothelial growth factor) are present in persons with
asthma, but the role (s) of VEGF in normal and asthmatic lungs has not been defined. We …
asthma, but the role (s) of VEGF in normal and asthmatic lungs has not been defined. We …
Importance of cytokines in murine allergic airway disease and human asthma
Asthma is a common, disabling inflammatory respiratory disease that has increased in
frequency and severity in developed nations. We review studies of murine allergic airway …
frequency and severity in developed nations. We review studies of murine allergic airway …
A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-κB pathway
Rationale: Persistent activation of nuclear factor (NF)-κB has been associated with the
development of asthma. Andrographolide, the principal active component of the medicinal …
development of asthma. Andrographolide, the principal active component of the medicinal …
Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production
MM Gueders, G Paulissen, C Crahay… - Inflammation …, 2009 - Springer
Objective Animal models of asthma mimic major features of human disease. Since the
genetic background of experimental animals might affect hyperresponsiveness and …
genetic background of experimental animals might affect hyperresponsiveness and …
Asthma therapy and airway remodeling
T Mauad, EH Bel, PJ Sterk - Journal of allergy and clinical immunology, 2007 - Elsevier
Asthma is characterized by variable degrees of chronic inflammation and structural
alterations in the airways. The most prominent abnormalities include epithelial denudation …
alterations in the airways. The most prominent abnormalities include epithelial denudation …
Treatment of allergic asthma: modulation of Th2 cells and their responses
B Bosnjak, B Stelzmueller, KJ Erb, MM Epstein - Respiratory research, 2011 - Springer
Atopic asthma is a chronic inflammatory pulmonary disease characterised by recurrent
episodes of wheezy, laboured breathing with an underlying Th2 cell-mediated inflammatory …
episodes of wheezy, laboured breathing with an underlying Th2 cell-mediated inflammatory …
T-helper cell type-2 regulation in allergic disease
SN Georas, J Guo, U De Fanis… - European respiratory …, 2005 - publications.ersnet.org
Substantial experimental evidence now supports the notion that allergic diseases are
characterised by a skewing of the immune system towards a T-helper cell type-2 (Th2) …
characterised by a skewing of the immune system towards a T-helper cell type-2 (Th2) …