Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

The field of bioinorganic chemistry is at a propitious stage of development. Ever more
complex metallobiomolecules are isolated and purified, physical methodologies and …

There have been significant advances in our understanding of mononuclear nonheme iron
oxygenases since our 1996 Chemical Reviews article, 1 promoted in large part by the many …

Reactive oxygen species (ROS) are known mediators of intracellular signal cascades.
Excessive production of ROS may lead to oxidative stress, loss of cell function, and cell …

The five-membered heterocyclic group of pyrazoles/pyrazolines plays important role in drug
discovery. Pyrazoles and pyrazolines present a wide range of biological activities. The …

Oxygen-activating enzymes with mononuclear nonheme iron active sites participate in many
metabolically important reactions that have environmental, pharmaceutical, and medical …

Lipoxygenases, which are widely distributed among plant and animal species, are Fe-
containing dioxygenases that act on lipids containing (Z, Z)-pentadiene moieties in the …

▪ Abstract Dioxygenases are nonheme iron-containing enzymes important in the
biosynthesis of plant signaling compounds such as abscisic acid, gibberellins, and ethylene …

Publisher Summary The bacterial aromatic ring-hydroxylating dioxygenases represent a
broad range of multi-component enzymes that possess many properties and mechanisms in …

In higher plants, the lipoxygenase enzymatic pathway combined actions of several enzymes
to convert lipid substrates into signaling and defense molecules called phytooxylipins …