Zinc: from biological functions to therapeutic potential

MI Costa, AB Sarmento-Ribeiro… - International Journal of …, 2023 - mdpi.com
The trace element zinc (Zn) displays a wide range of biological functions. Zn ions control
intercellular communication and intracellular events that maintain normal physiological …

[HTML][HTML] The role of zinc in antiviral immunity

SA Read, S Obeid, C Ahlenstiel, G Ahlenstiel - Advances in nutrition, 2019 - Elsevier
Zinc is an essential trace element that is crucial for growth, development, and the
maintenance of immune function. Its influence reaches all organs and cell types …

Critical role of zinc as either an antioxidant or a prooxidant in cellular systems

SR Lee - Oxidative medicine and cellular longevity, 2018 - Wiley Online Library
Zinc is recognized as an essential trace metal required for human health; its deficiency is
strongly associated with neuronal and immune system defects. Although zinc is a redox …

Redox-and non-redox-metal-induced formation of free radicals and their role in human disease

M Valko, K Jomova, CJ Rhodes, K Kuča… - Archives of toxicology, 2016 - Springer
Transition metal ions are key elements of various biological processes ranging from oxygen
formation to hypoxia sensing, and therefore, their homeostasis is maintained within strict …

[HTML][HTML] The physiological, biochemical, and molecular roles of zinc transporters in zinc homeostasis and metabolism

T Kambe, T Tsuji, A Hashimoto… - Physiological …, 2015 - journals.physiology.org
Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

[HTML][HTML] Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis

T Hara, T Takeda, T Takagishi, K Fukue… - The Journal of …, 2017 - Elsevier
Zinc (Zn) is an essential trace mineral that regulates the expression and activation of
biological molecules such as transcription factors, enzymes, adapters, channels, and growth …

Metalloimmunology: The metal ion-controlled immunity

C Wang, R Zhang, X Wei, M Lv, Z Jiang - Advances in immunology, 2020 - Elsevier
Metals are essential components in all forms of life required for the function of nearly half of
all enzymes and are critically involved in virtually all fundamental biological processes …

[HTML][HTML] Biomarkers of Nutrition for Development (BOND)—zinc review

JC King, KH Brown, RS Gibson, NF Krebs… - The Journal of …, 2016 - Elsevier
Zinc is required for multiple metabolic processes as a structural, regulatory, or catalytic ion.
Cellular, tissue, and whole-body zinc homeostasis is tightly controlled to sustain metabolic …

Zinc in cellular regulation: the nature and significance of “zinc signals”

W Maret - International journal of molecular sciences, 2017 - mdpi.com
In the last decade, we witnessed discoveries that established Zn2+ as a second major
signalling metal ion in the transmission of information within cells and in communication …

Zinc signals and immunity

M Maywald, I Wessels, L Rink - International journal of molecular sciences, 2017 - mdpi.com
Zinc homeostasis is crucial for an adequate function of the immune system. Zinc deficiency
as well as zinc excess result in severe disturbances in immune cell numbers and activities …