BACKGROUND A normal chromosomal constitution defined through PGT-A assessing all
chromosomes on trophectoderm (TE) biopsies represents the strongest predictor of embryo …

BACKGROUND Preimplantation genetic testing (PGT) encompasses methods that allow
embryos to be tested for severe inherited conditions or for chromosome abnormalities …

Advanced maternal age (AMA;> 35 year) is associated with a decline in both ovarian
reserve and oocyte competence. At present, no remedies are available to counteract the …

Contrary to widespread belief, the implantation of an embryo for the initiation of pregnancy is
like a battle, in that the embryo uses a variety of coercive tactics to force its acceptance by …

Failure of embryo implantation is a major limiting factor in early pregnancy and assisted
reproduction. Determinants of implantation include the embryo viability, the endometrial …

Extracellular vesicles are lipoproteinaceous membrane-enclosed nanometer-sized
structures produced by cells and are thought to mediate cellular communications. Loaded …

Communication between embryo and maternal endometrium occurs during a specific time
frame in which implantation is possible. Here we demonstrate for the first time that …

Expression of microRNAs (miRNAs) is essential for embryonic development and serves
important roles in gametogenesis. miRNAs are secreted into the extracellular environment …

BACKGROUND DNA damage is a hazard that affects all cells of the body. DNA-damage
repair (DDR) mechanisms are in place to repair damage and restore cellular function, as are …

In this study, for the first time, we demonstrated the presence of microRNAs and extracellular
vesicles in human blastocoel fluid. The bioinformatic and comparative analyses identified …