The hypocretins (Hcrts), also known as orexins, are two neuropeptides produced exclusively
in the lateral hypothalamus. They act on two specific receptors that are widely distributed …

The orexin-A/hypocretin-1 and orexin-B/hypocretin-2 are neuropeptides synthesized by a
cluster of neurons in the lateral hypothalamus and perifornical area. Orexin neurons receive …

Physical exercise may improve cognitive function by modulating molecular and cellular
mechanisms within the brain. We propose that the facilitation of long-term synaptic …

Orexins, or hypocretins, are excitatory neuropeptides involved in the regulation of feeding
behavior and the sleep and wakefulness states. Since their discovery, several lines of …

The neuropeptides orexins are important in regulating the neurobiological systems that
respond to stressful stimuli. Furthermore, orexins are known to play a role many of the …

In the present article, we provide a brief review of current knowledge regarding the effects
induced by physical exercise on hippocampus. Research involving animals and humans …

Background Cognitive impairment has long challenged the patients with major depressive
disorder (MDD), hypocretins and inflammation have recently been implicated in cognitive …

Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by
cognitive deficits and neuronal loss. Deposition of beta-amyloid peptide (Aβ) causes …

Hcrt gene inactivation in mice leads to behavioral state instability, abnormal transitions to
paradoxical sleep, and cataplexy, hallmarks of narcolepsy. Sleep homeostasis is, however …

Midlife obesity is a risk factor for cognitive decline and is associated with the earlier onset of
Alzheimer's disease (AD). Diets high in saturated fat potentiate the onset of obesity …