Bile acids (BAs) can regulate their own metabolism and transport as well as other key
aspects of metabolic homeostasis via dedicated (nuclear and G protein-coupled) receptors …

Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …

Emerging evidence points to a strong association between the gut microbiota and the risk,
development and progression of gastrointestinal cancers such as colorectal cancer (CRC) …

The gut microbiota is profoundly involved in glucose and lipid metabolism, in part by
regulating bile acid (BA) metabolism and affecting multiple BA-receptor signaling pathways …

Colorectal cancer (CRC) risk is predominantly driven by environmental factors, in particular
diet. A high intake of dietary fat has been implicated as a risk factor inducing the formation of …

The gut microbiota represents a 'metabolic organ'that can regulate human metabolism. Intact
gut microbiota contributes to host homeostasis, whereas compositional perturbations …

Background Prenatal exposures to per-and polyfluoroalkyl substances (PFAS) have been
linked to reduced fetal growth. However, the detailed molecular mechanisms remain largely …

Bile salts and bacteria have intricate relationships. The composition of the intestinal pool of
bile salts is shaped by bacterial metabolism. In turn, bile salts play a role in intestinal …

Bile acids are cholesterol-derived surfactants that circulate actively between the liver and
ileum and that are classically recognized for emulsifying dietary lipids to facilitate absorption …

Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial
pathophysiological process that cannot yet be recapitulated in a single in vitro model …